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Islet transplantation may correct type 1 diabetes, study says

48 pointsby aethertapabout 9 years ago

5 comments

lolcabout 9 years ago
As a type 1 I&#x27;m obviously interested in such development. But if they do it only &quot;for people unable to safely control type 1 diabetes&quot; there must be a serious downside.<p>Ah, they only say this in the image caption but you have to take the immunosuppressives forever to keep the injected cells. Some of my own cells are still alive so I could just start taking these drugs to protect them from my immune system. I don&#x27;t think I want to though.
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ivan_ahabout 9 years ago
Very interesting and promising.<p>A related approach is to implant the islets in a &quot;pocket&quot; under the skin, which supposedly is easier to monitor and requires less immuno-suppressing drugs [1,2].<p>[1] <a href="http:&#x2F;&#x2F;www.nature.com&#x2F;nbt&#x2F;journal&#x2F;v33&#x2F;n5&#x2F;full&#x2F;nbt.3216.html" rel="nofollow">http:&#x2F;&#x2F;www.nature.com&#x2F;nbt&#x2F;journal&#x2F;v33&#x2F;n5&#x2F;full&#x2F;nbt.3216.html</a> &quot;mirrored&quot; here <a href="http:&#x2F;&#x2F;www.cnd.mcgill.ca&#x2F;~ivan&#x2F;Papers&#x2F;islets_nbt.3216.pdf" rel="nofollow">http:&#x2F;&#x2F;www.cnd.mcgill.ca&#x2F;~ivan&#x2F;Papers&#x2F;islets_nbt.3216.pdf</a> [2] <a href="http:&#x2F;&#x2F;www.pnas.org&#x2F;content&#x2F;110&#x2F;47&#x2F;19054.full.pdf" rel="nofollow">http:&#x2F;&#x2F;www.pnas.org&#x2F;content&#x2F;110&#x2F;47&#x2F;19054.full.pdf</a>
andyflemingabout 9 years ago
I imagine this approach is less effective than another recent approach where they put &quot;insulin-making islet cells onto a layer of fat in the recipient’s abdomen&quot;, right? (<a href="http:&#x2F;&#x2F;www.endocrineweb.com&#x2F;news&#x2F;diabetes&#x2F;17843-no-more-insulin-shots-thanks-new-type-islet-cell-transplant" rel="nofollow">http:&#x2F;&#x2F;www.endocrineweb.com&#x2F;news&#x2F;diabetes&#x2F;17843-no-more-insu...</a>)
manicdeeabout 9 years ago
Grafting islets onto kidneys was being trialled in rats a decade ago. It pains me to see how slowly medical science progresses.
andyflemingabout 9 years ago
Will this be able to be used in combination with the growth of Beta cells? (<a href="http:&#x2F;&#x2F;hsci.harvard.edu&#x2F;diabetes-0" rel="nofollow">http:&#x2F;&#x2F;hsci.harvard.edu&#x2F;diabetes-0</a>)