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Grail: Pan-cancer blood screening test for circulating tumor DNA

41 pointsby fitzwatermellowabout 9 years ago

4 comments

eganistabout 9 years ago
Disclaimer: medicine isn&#x27;t my background, so the following comment could be partially or entirely groundless.<p>---<p>So I just took a crack at the concept PDF and the rest of the literature on the site, and there&#x27;s nothing that I can find which mitigates the risk of flagging a slow-growing or self-regressing tumor as something worthy of attention.<p>I say this because mammogram recommendations were only recently changed due to the potential adverse health risks stemming from treating tumors which might never progress to a severity warranting treatment [1] as well as tumors which might spontaneously regress [2]. If some of the newer oncology theories suggesting high tumor occurrence and anti-cancer immune responses are correct (my google-fu didn&#x27;t help me here, so someone else might want to help me with the source), then as a result of Grail, you might start having a bunch of people freak out and undergo unnecessarily heavy treatments for tumors which might otherwise never become cancerous.<p>That said, I could be entirely wrong, and I wouldn&#x27;t be surprised if they&#x27;re specifically working on mitigating this risk as one component of making this screen viable.<p>[1]<a href="http:&#x2F;&#x2F;www.webmd.com&#x2F;breast-cancer&#x2F;features&#x2F;new-mammogram-screening-guidelines-faq?page=2" rel="nofollow">http:&#x2F;&#x2F;www.webmd.com&#x2F;breast-cancer&#x2F;features&#x2F;new-mammogram-sc...</a><p>[2]<a href="http:&#x2F;&#x2F;archinte.jamanetwork.com&#x2F;article.aspx?articleid=773446" rel="nofollow">http:&#x2F;&#x2F;archinte.jamanetwork.com&#x2F;article.aspx?articleid=77344...</a>
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greggmanabout 9 years ago
Whatever happened to this which as supposed to also detect all cancers for $0.01 per test at &gt; 99% accuracy?<p><a href="https:&#x2F;&#x2F;www.ted.com&#x2F;talks&#x2F;jack_andraka_a_promising_test_for_pancreatic_cancer_from_a_teenager?language=en" rel="nofollow">https:&#x2F;&#x2F;www.ted.com&#x2F;talks&#x2F;jack_andraka_a_promising_test_for_...</a>
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jerryhuang100about 9 years ago
i am surprised that neither in their job opening, or exec board or advisory board there&#x27;s someone with specialization in gov regulation or legal matters (except an opening for dir. of IP).
untilHellbannedabout 9 years ago
Lots of scientist prowess except the CEO. Not ideal.
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