TE
TechEcho
Home24h TopNewestBestAskShowJobs
GitHubTwitter
Home

TechEcho

A tech news platform built with Next.js, providing global tech news and discussions.

GitHubTwitter

Home

HomeNewestBestAskShowJobs

Resources

HackerNews APIOriginal HackerNewsNext.js

© 2025 TechEcho. All rights reserved.

Magic mushrooms found to lift severe depression in clinical trial

173 pointsby torusabout 9 years ago

26 comments

exeliusabout 9 years ago
From personal experience in my youth, I can definitely say that psychedelics (mushrooms in particular) can help you think in different ways that make your problems seem trivial and imminently solvable. Those changed patterns of thought seem like a revelation at the time -- like the clouds opened and an answer came down from the sky. So I&#x27;m not at all surprised with this.<p>That said, this study had only 12 participants with no control group -- so it&#x27;s hard to draw any meaningful conclusions. But as a canary study, it says that there might be something here, so further, more rigorous studies are warranted.
评论 #11716042 未加载
评论 #11715529 未加载
评论 #11719583 未加载
humbleMouseabout 9 years ago
When I am finishing a mushroom experience I usually have overwhelming feelings of love and am excited to start the next day. My brain is racing with all the possibilities of life and ways I can make things better for myself.<p>People should be coached in how to have a good mushroom experience and what to expect. Nature + fresh fruit + good music + comfy place to sleep has always been a winning combination for me.
评论 #11715675 未加载
评论 #11715573 未加载
评论 #11715657 未加载
评论 #11715713 未加载
评论 #11715420 未加载
评论 #11715544 未加载
评论 #11716159 未加载
primitivesuaveabout 9 years ago
For those seeking to break down the barriers of the mind, psilocybin and mescaline are the most intelligent options. SWIM (Someone Who Isn&#x27;t Me) grew mushrooms and peyote cactus to enable revelations in the minds of consenting adults, and every single person who ingested these naturally-occurring organic substances thanked SWIM for a life-changing experience.<p>That said, there are obvious risks to glorifying psychedelic use, especially when available psychedelics are usually in the form of LSD. While these synthetic compounds can yield the same results as their organic counterparts, there is no way to verify the amount of LSD in a dose. Overdosing on LSD can trigger schizophrenia and several other mental problems in those who are prone to it. This is why SWIM recommends organic psychedelic compounds that can be clearly measured into an appropriate dosage for the individual&#x27;s size and past psychedelic experience.<p>There is also an overwhelming trend amongst unscrupulous suppliers to market doses of DOC (<a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;2,5-Dimethoxy-4-chloroamphetam..." rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;2,5-Dimethoxy-4-chloroamphetam...</a>) as LSD. While the observed effect of the two are similar, DOC can be extremely dangerous to those with hypertension and high blood pressure. DOC is also an amphetamine with greater risk of physical addiction.<p>SWIM also wants to point out that SWIM engaged in countless adventures with varying levels of psilocybin and mescaline dosages, and arrived at the conclusion that psychedelic substances are not necessary for seeing the beauty in life or the purpose that one may have in this world. SWIM&#x27;s most transformative revelations came about while completely sober at a Taoist monastery of the Wudang mountains in China. It is SWIM&#x27;s opinion that all can know beauty as beauty only because there is ugliness (Tao Te Ching, chapter 2), and now urges people to pursue safe and well-known techniques (meditation, yoga, tai chi, qi gong) for improving one&#x27;s state of mind.
评论 #11717541 未加载
apoabout 9 years ago
From the study:<p>&gt; A logical next step would be to carry out a placebo controlled randomised trial in which the level of therapist contact is consistent between conditions.<p><a href="http:&#x2F;&#x2F;www.thelancet.com&#x2F;pb&#x2F;assets&#x2F;raw&#x2F;Lancet&#x2F;pdfs&#x2F;S2215036616300657.pdf" rel="nofollow">http:&#x2F;&#x2F;www.thelancet.com&#x2F;pb&#x2F;assets&#x2F;raw&#x2F;Lancet&#x2F;pdfs&#x2F;S22150366...</a><p>Depression studies are subject to well-known, powerful placebo effects, rendering this study&#x27;s conclusions next to useless:<p><a href="http:&#x2F;&#x2F;blogs.scientificamerican.com&#x2F;cross-check&#x2F;are-antidepressants-just-placebos-with-side-effects&#x2F;" rel="nofollow">http:&#x2F;&#x2F;blogs.scientificamerican.com&#x2F;cross-check&#x2F;are-antidepr...</a>
评论 #11716219 未加载
评论 #11716285 未加载
评论 #11716240 未加载
评论 #11719110 未加载
ifnautabout 9 years ago
I owe my entire successful career in science and mathematics to repeated use of LSD in my late teens&#x2F;early 20&#x27;s. It woke my desire to seek answers to the underlying mechanics of the universe. Before that, I was just a high school drop-out with low self-esteem, no direction, and no positive role models.
评论 #11716840 未加载
Torgoabout 9 years ago
It worked for me in my 20&#x27;s, but I think if I tried it again in my late 30&#x27;s, it might make things worse. Mushrooms don&#x27;t let you hide problems from yourself.
评论 #11716199 未加载
评论 #11715856 未加载
评论 #11715376 未加载
评论 #11715520 未加载
评论 #11719135 未加载
sevabout 9 years ago
&gt; It took 32 months between having the grant awarded and dosing the first patient, says Nutt. By comparison, it took six months “to get through the machinations” for his team’s previous studies using the equally illegal drugs LSD and MDMA, he says.<p>I thought we were making progress...
nxzeroabout 9 years ago
Says more about how poorly the brain is understood than anything else.<p>Also, very possible that the measures that were take to keep people &quot;safe&quot; were a factor. Anyone know if there was a control group given the same treatment (double blind) - but with a placebo? __________<p>EDIT:<p>Direct link to the related research paper:<p>Psilocybin for treatment-resistant depression: a feasibility study<p><a href="http:&#x2F;&#x2F;www.thelancet.com&#x2F;pb&#x2F;assets&#x2F;raw&#x2F;Lancet&#x2F;pdfs&#x2F;S2215036616300657.pdf" rel="nofollow">http:&#x2F;&#x2F;www.thelancet.com&#x2F;pb&#x2F;assets&#x2F;raw&#x2F;Lancet&#x2F;pdfs&#x2F;S22150366...</a>
评论 #11717427 未加载
评论 #11715502 未加载
stuxnet79about 9 years ago
Is there any literature in their efficacy in treating anxiety disorders? As somebody who&#x27;s suffered from severe anxiety since my mid-teens and had it cleared up more or less from medication I&#x27;m extremely interested in seeing how Psilocybin would affect the disorder. I would be quite willing to try it out but I&#x27;m very hesitant because I suspect my underlying anxiety would undermine the experience and possibly leave me in a worse off state than before.
评论 #11716564 未加载
评论 #11716642 未加载
评论 #11716521 未加载
pasbesoinabout 9 years ago
More anecdote leaning towards truth that my friends were self-medicating and not simply &quot;doing something bad.&quot;<p>I am now, well into middle age, firmly in the camp that I missed out, due to fear, propaganda, and mis-information. And that my life might have been much better if I had not bought so heavily into that message and instead had &quot;experimented&quot;. Trust your observations; not blind authority.<p>Anyway... I&#x27;m currently trying to overcome a combination of symptoms, thoughts, and feelings, stemming from years of abuse, PTSD, and eventually significant knock-on physical health effects.<p>In the past, I&#x27;ve tried SSRI&#x27;s, NSRI&#x27;s, Wellbutrin. Immediate, horrible reactions to each. The only thing that helped was a small dose of Adderall -- much lower than standard. And St. John&#x27;s Wort. Almost impossible in the U.S. to find a doctor who will agree to simultaneous use of both -- unlike in Europe, so I understand. And the doctor I found was a jerk who almost cost me my chance to purchase next year&#x27;s health insurance, due to his lack of response on paperwork. So, no more Adderall.<p>I&#x27;m ready to try magic mushrooms. Maybe a low, pure dose of ketamin. Or perhaps MDMA. Under supervision -- medical or simply experienced and well-intentioned. But, there is no avenue for this.<p>And big pharma and the &quot;war on drugs&quot; will do their best to keep it locked down.<p>I simply have no trust left in the Establishment, in the U.S., with respect to medical practice. Or, very select trust, in individual practitioners. Who are often caught in a system that severely hampers their ability to actually practice effective medicine and treatment.
评论 #11718662 未加载
kolapuriyaabout 9 years ago
I really do believe some of the more negative stereotypes and stigma is beginning to lift surrounding the therapeutic use of entheogens. Like you stated time and accurate information with disciplined research hopefully leads to change. I think we have all seen that occur with marijuana for both medical and recreational use. I am very optimistic about the future of psychedelic use for those that need it and those that desire it.
alvaabout 9 years ago
Lots of people with positive experiences with psilocybin in this thread. I have also had many incredible experiences and advocate its use, with conditions. But. And this is a very important thing to know before anyone reading decides to try it for the first time.<p>Psilocybin experiences can be truly traumatic. If you have existing mental health issues, please be very, very careful before you decide to take it. Do all the research you can. I have one friend who went completely over the edge, reached the point of no return. It triggered a predisposition to a horrible mental illness. It has destroyed his life and his familys. For a small number of people, this can happen.<p>If you think you might be vulnerable to this but still want to go ahead, please make sure you are responsibly and get an experienced sitter and a safe, familiar setting.
评论 #11718508 未加载
peterwwillisabout 9 years ago
I like how marijuana and psilocybin have no negative side effects and it&#x27;s taken hundreds of years to be taken seriously as clinical treatments.<p>Meanwhile, according to the FDA, there were &quot;56,000 emergency room visits, 26,000 hospitalizations, and 458 deaths per year related to acetaminophen-associated overdoses during the 1990s. unintentional acetaminophen overdose accounted for nearly 25 percent of the emergency department visits, 10 percent of the hospitalizations, and 25 percent of the deaths [per year].&quot; [1]<p>[1] <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Paracetamol#Liver_damage" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Paracetamol#Liver_damage</a>
joesmoabout 9 years ago
The irony of psilocybin classification as a Schedule 1 drug is that it&#x27;s not even addictive. But then again, the US government and America in general has never let facts get in the way of their goals to ruin people&#x27;s lives. People have known this is an effective treatment for depression for many years. How many lives have been ruined simply because of its being illicit and unavailable to treat patients who needed it? When I think about it that way, I can&#x27;t help but hope these murderers will one day get justice, but I know they won&#x27;t.
niccaluimabout 9 years ago
Twelve people. No control group. And as a person who has suffered lifelong depression, and up until 2.5 years ago had serious substance problems: duh, drugs change the way you feel.<p>I&#x27;m not saying there&#x27;s nothing worth exploring here. My personal intuition is that psychedelics could be a huge help in some cases, especially for treatment-resistant depression. But this &quot;study&quot; isn&#x27;t worth squat.
notadocabout 9 years ago
On a similar note, there are many studies about ketamine administration (the anesthetic) having positive impacts on depression and chronic pain.<p>There are ongoing clinical trials, it has been widely covered in media lately, and many major US cities have doctors who run ketamine clinics.<p><a href="https:&#x2F;&#x2F;clinicaltrials.gov&#x2F;ct2&#x2F;show&#x2F;NCT00088699" rel="nofollow">https:&#x2F;&#x2F;clinicaltrials.gov&#x2F;ct2&#x2F;show&#x2F;NCT00088699</a><p><a href="http:&#x2F;&#x2F;nymag.com&#x2F;scienceofus&#x2F;2016&#x2F;03&#x2F;what-its-like-to-treat-severe-depression-with-a-hallucinogenic-drug.html" rel="nofollow">http:&#x2F;&#x2F;nymag.com&#x2F;scienceofus&#x2F;2016&#x2F;03&#x2F;what-its-like-to-treat-...</a><p><a href="http:&#x2F;&#x2F;www.npr.org&#x2F;sections&#x2F;health-shots&#x2F;2015&#x2F;09&#x2F;28&#x2F;443203592&#x2F;club-drug-ketamine-gains-traction-as-a-treatment-for-depression" rel="nofollow">http:&#x2F;&#x2F;www.npr.org&#x2F;sections&#x2F;health-shots&#x2F;2015&#x2F;09&#x2F;28&#x2F;44320359...</a><p>Is it really surprising to anyone that mind altering chemicals could alter mental states? A silly question, obviously.
jarmitageabout 9 years ago
This is more excellent work by ICL and the Beckley Foundation. Science is rapidly changing in this area.<p>Check out their publications list from this year alone, a few world firsts in there:<p><a href="http:&#x2F;&#x2F;beckleyfoundation.org&#x2F;resources&#x2F;science-publications&#x2F;" rel="nofollow">http:&#x2F;&#x2F;beckleyfoundation.org&#x2F;resources&#x2F;science-publications&#x2F;</a>
trhwayabout 9 years ago
i think we&#x27;ll be looking back at our time with amusement to say the least - these people, like millions others, were having serious problems for decades (17.8 years avg in the article) while known remedies like cannabis, mushrooms and other stuff is just prohibited out of the irrational fear and powergrab desire driving the war on drugs.
pigpawsabout 9 years ago
Legalize, standardize, tax, repeat. Why is it that difficult? People will do anything to keep their grip on (perceived) power - even if it means destroying someone&#x27;s life.<p>Gov&#x27;t doesn&#x27;t really want jobs, or tax revenue at the expense of their jobs. What would cops do if they weren&#x27;t locking up kids for a joint?
评论 #11715971 未加载
评论 #11715961 未加载
评论 #11716156 未加载
Alex3917about 9 years ago
Does anyone know what species is in the picture? Someone on the Flickr page asks if they&#x27;re Cyanescens. My guess would be Allenii just based on the fact that they were found in San Bruno, but I don&#x27;t have a good species concept for either.
sageikosaabout 9 years ago
Going through that whole process to run the trial could easily lead to depression.
trubabout 9 years ago
I&#x27;m shocked!
sageabillyabout 9 years ago
It&#x27;s great to see the advances in research that are being done around Psilocybin, MDMA, and Ketamine as the results that are coming out look incredibly promising.<p>That being said, godDAMN how in the hell is anyone ever going to take studies like this seriously when they&#x27;re being reported as &quot;Magic Mushrooms&quot; in Scientific American of all places? This isn&#x27;t raver kiddies eating dried who-knows-what out of ziplock bags at raves, this is a controlled dosing of psilocybin in a medical setting for treatment of a serious illness. The stigma around researching these drugs is never going to go away unless the language itself changes.
评论 #11715844 未加载
评论 #11715650 未加载
评论 #11715681 未加载
评论 #11716229 未加载
评论 #11716204 未加载
评论 #11715568 未加载
trubabout 9 years ago
not surprised
mickgilesabout 9 years ago
They needed a study to show that magic mushrooms make you happy? That is why they are called &quot;magic&quot; mushrooms
jtwebmanabout 9 years ago
12 people isn&#x27;t a scientific study! Where is the control group? I think maybe we need a few more studies before people go out and start eating magic mushrooms to not be depressed.
评论 #11716819 未加载