I highly recommend Pylons for Python web development. It's not a "how to build an app in 10 minutes" framework.<p>I don't see frameworks as tools that novices should use to build applications quickly. I see frameworks as tools that experienced developers can use to eliminate grunt work. I actually like Pylons for not doing too much and giving me choices every step of the way. I can use the bits I need and customize everything else.<p>But it depends on what you're looking for.
I tried pylons not too long ago. I liked the general idea but I ran into several problems. Building the sample didn't work out of the gate and I had to dig around the site to figure out what was wrong. I never could get the user authentication stuff (AuthKit) working with the latest version of Pylons. I finally decided that I'd rather not spend my time debugging or rewriting the framework, even if it does give me more choice.