The really interesting part of this is the python-to-javascript conversion, which appears to be based on this:
<a href="http://davidf.sjsoft.com/files/py2js" rel="nofollow">http://davidf.sjsoft.com/files/py2js</a>
While this is similar to Aptana's Jaxer project, Jaxer does <i>server-side</i> DOM stuff just as easily as client-side DOM stuff. I'm having a hard time imagining this framework does that. The only DOM stuff in the example is marked as clientside. With Jaxer, they actually have JQuery running serverside. I'm not sure how pyxer could even make use of JQuery clientside (or other frameworks).