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The spleen, the strange little organ that can multiply

97 pointsby Meeraxover 8 years ago

6 comments

Asparagirlover 8 years ago
Oh hey, this is me! I had two accessory spleens. But the bad news is that ALL of them absolutely had to come out -- the accessories were discovered during a medically necessary splenectomy.<p>As the article says, the spleen filters your red blood cells and platelets. Think of it like a swimming pool filter for your blood stream. It knows which cells to break down because they&#x27;re misshapen, spherical, instead of the &quot;donut without a hole&quot; shape. RBC&#x27;s live about three months before degrading like that.<p>There&#x27;s just one problem: what happens if your red blood cells are ALL funny-shaped, even the young healthy ones? Why then, your spleen valiantly tries to catch &#x27;em all, like Pokémon, and you end up breaking down your own blood supply, auto-hemolytic anemia.<p>Welcome to hereditary spherocytosis, which is what I have. Despite its name, it was not hereditary in my case; about 25% of cases are de novo mutations. Incidence is about 1 in 6500, though some milder cases go undetected.<p>So, after a childhood of jaundice at birth, inexplicable anemia, paleness, and just being really really tired all the time, finally at age six did my pediatrician notice that my spleen was massively enlarged (due to working overtime) and two years later I had to have it out, along with the two accessories they discovered on the operating table. This was the late 1980&#x27;s so I juuust missed the beginning of the era of laparoscopic surgery, so I have a heck of an abdominal scar.<p>Poor little spleen, it was only trying to do its job. The fault lay with my blood, not with it.<p>Meanwhile, I&#x27;m immune-compromised for life and have to stay on top of all kinds of vaccines. Note to other spleenless wonders posting here: there&#x27;s a brand new Meningitis Type B vaccine that just came out in late 2014; get on that. Also Prevnar, Pneumovax, annual flu shots and all the other fun stuff.
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shaknaover 8 years ago
I had a secondary spleen, nestled right up against my main one that I tore completely in half in primary school.<p>Subsequent testing over the next five years showed it, sadly, failed to become active.<p>For people like me, getting your inoculations is imperative. Annual gp visits help keep it in check.<p>As for the rest, depending on herd immunity is the answer.
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pacaroover 8 years ago
Shame that the article doesn&#x27;t mention how we know so much about long term survival rates of people with no spleen. IIRC During the Second World War (aka WWII) large numbers of injured soldiers had their spleens removed in passing, this gave a large population to follow
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rajuvegesnaover 8 years ago
Nothing was mentioned about multiple spleens at birth (Polysplenia). Yes, some people are born with multiple spleens. In such case, it has nothing to do with injury and there doesn&#x27;t seem to be enough knowledge on why this occurs.<p>Multiple spleens often result in mis-diagnosis (during radiology) leading to wrong treatment. When you know you have accessory spleens, it is always good to give them a heads up.
justinatorover 8 years ago
Any research done to nudge these spleen cells into making other types of cells (stem)?
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stcredzeroover 8 years ago
A housemate of mine used to call herself &quot;The spleenless wonder.&quot; It was removed after a car accident.
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