Gwern did some self-experimentation with LSD and didn't find any significant effects: <a href="https://www.gwern.net/LSD%20microdosing" rel="nofollow">https://www.gwern.net/LSD%20microdosing</a>
Amanda Feilding, who this article is about, is a fascinating person. In the 70s she drilled a hole in her own skull ("trepanation"), then ran for political office to promote the benefits of that operation. She's now Countess of Wemyss and March, married to a similarly-trepanned Earl.<p><a href="http://cabinetmagazine.org/issues/28/turner.php" rel="nofollow">http://cabinetmagazine.org/issues/28/turner.php</a>