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Low-dose suramin temporarily improves symptoms of autism in small-scale study

83 pointsby jsnathanalmost 8 years ago

6 comments

blennonalmost 8 years ago
Robert Naviaux is the real deal and his theory on the Cell Danger Response is fascinating [1]. In addition to ASD, he recently made a significant discovery in the characterization of Chronic Fatigue Syndrome as a metabolic illness [2].<p>[1] <a href="http:&#x2F;&#x2F;naviauxlab.ucsd.edu&#x2F;wp-content&#x2F;uploads&#x2F;2016&#x2F;09&#x2F;cell_danger_response.pdf" rel="nofollow">http:&#x2F;&#x2F;naviauxlab.ucsd.edu&#x2F;wp-content&#x2F;uploads&#x2F;2016&#x2F;09&#x2F;cell_d...</a> [2] <a href="http:&#x2F;&#x2F;naviauxlab.ucsd.edu&#x2F;wp-content&#x2F;uploads&#x2F;2016&#x2F;08&#x2F;PNAS-2016-Naviaux-1607571113.pdf" rel="nofollow">http:&#x2F;&#x2F;naviauxlab.ucsd.edu&#x2F;wp-content&#x2F;uploads&#x2F;2016&#x2F;08&#x2F;PNAS-2...</a>
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SubiculumCodealmost 8 years ago
This might help some aspects of ASD. Hopefully. However I do not see how it will reverse the altered neural migration occurring early in development, for example, unless it is administered in infancy or earlier while in the womb..
Darvictalmost 8 years ago
<a href="https:&#x2F;&#x2F;en.m.wikipedia.org&#x2F;wiki&#x2F;Suramin" rel="nofollow">https:&#x2F;&#x2F;en.m.wikipedia.org&#x2F;wiki&#x2F;Suramin</a><p>Things to note:<p>- Administered solely by injection.<p>- Not FDA approved.
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valuearbalmost 8 years ago
Only 5 kids each for test and control populations.
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donquichottealmost 8 years ago
From TFA: &quot;Suramin works by inhibiting the signaling function of adenosine triphosphate (ATP), a nucleotide or small molecule produced by cellular mitochondria and released from the cell as a danger signal. When CDR is activated, the effect of extracellular ATP is similar to a warning siren that never stops. Suramin inhibits the binding of ATP and similar molecules to key purinergic receptors, according to Naviaux.&quot;<p>Are there any other substances out there that inhibit ATP signaling?
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lula68almost 8 years ago
Back at it again with pretending autistic people don&#x27;t become adults and can&#x27;t communicate at all?
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