An interesting area investment wise. Really don't know what to make of it as I do see a great deal of risk in these companies personally, that somehow others are happy with.<p>No real products, no real roadmap. Jim has also made some very bad pharma calls in the past and had some very clueless people running his pharma companies. That said he looks to have done some real research.<p>> The primary game plan at Juvenescence, explains Bailey, is to come up with various operations engaged in developing new anti-aging drugs<p>> Juvenescence Bio will be charged with building the pipeline, says Bailey, in part with the molecules that will be identified through the AI venture.<p>To me that's a warning sign. I like the ambition. This is Elon Musk level stuff. But he isn't crazy enough to deal in unproven potential outcomes. He knew rockets can go to space, he knew electric cars can drive, he knew batteries can store energy/money. He knew what he could sell when he solved the issues<p>Here i'm not sure they know what they will have in the end and that would scare me off.
This is an interesting case where it's hard to separate rationality from human nature. On the one hand, people don't want to lose their investment. On the other hand, people really, really don't want to die. So as billionaires get older, they are going to feel a lot of psychological pressure to believe life-extension startup stories they might not find as credible in another context.<p>I think one nice way to solve this is to require a small, objective proof of concept for startups claiming to have a rejuvenating technology.<p>I propose they solve baldness. It will not only demonstrate the technology, but remove the funding problem entirely.
If Juvenescence puts serious effort into senolytics, then this will be useful. The more the merrier in that field to join Unity Biotechnology, Oisin Biotechnologies, SIWA Therapeutics, etc.<p>Everything else outside the SENS portfolio that can be accomplished via drug discovery to alter the operation of metabolism, focusing on known targets such as mTOR, is most likely a pointless waste of time and energy. It has been a pointless waste of time and energy for the past two decades, and I don't see that changing any time soon. The approach of trying to mimic calorie restriction or upregulate autophagy or mess with growth hormone/insulin metabolism or mimic exercise has very definite upper bounds on effectiveness.<p>The longevity dividend promise of "spend billions to add a couple of years of life expectancy by 2040" is underwhelming, and anyone out there talking about drug discovery to alter metabolism to slow aging is in that camp.<p>If billions are to be spent, then use them to follow the SENS approach of damage repair, not tinkering the system to slightly slow down the pace of damage accumulation. Only damage repair, such as via senolytics to clear senescent cell accumulation, can in principle produce rejuvenation of the old and greatly extended healthy life spans, more than just a few years.<p>It is not a coincidence that senescent cell clearance has in a few short years, just as soon as people started to try it in earnest, proven itself far more effective and reliable and useful than the past 20 years of people trying to mimic calorie restriction or boost autophagy.
It's great how trying to live forever went from being considered impossible to something that Google and many billionaires are investing a lot of money into. I think Aubrey de Grey had a lot to do with this by making the SENS approach which has helped properly characterize the types of cellular damage attributable to aging.
I've had my immortality rings from Alex Chiu for years now. They should just talk to him.<p><a href="http://alexchiu.com/" rel="nofollow">http://alexchiu.com/</a>
Tier 1 entrepreneur gives the masses what they want. Tier 2 gives the masses what they should want, and makes them want it. Tier 3 saves their lives so they have time to learn to want better things. Med tech is best tech. It also relies on much of the fun tech.
I'm worried about my brain more than the other parts of my body. I can do something to stay relatively health but my brain will shrink into a raisin no matter what I do.
Death will become optional at some point. But it will be only for the rich. Death was always this great equalizer. With that not being the case there will be a revolt on the size and proportion humanity would not have seen. how do we deal with that?
Anti-aging is for future. For now<p>ban smokes/alcohol
tax fat/sugar<p>for those causing accidents, make them pay the hospital bills and eliminate unemployment. Law cannot stop injustice, which reduces quality of life, but can make people feel that someone is by their side, which increases quality of life.