Problems with this terrible title:<p>1. In vitro petri dish testing is a million light years away from showing a compound works in humans.<p>2. This is a particularly bad problem in brain diseases as getting your compound to cross the blood-brain barrier in correct therapeutic quantities is extremely difficult.<p>3. We have lots of direct antibodies that kill beta amyloid in vivo that are very advanced in human trials. The problem now is that they often cause micro-damage when removing various forms of amyloid protein or have been shown to be administered far too late when the damage is already done.<p>4. It's still not clear that beta amyloid is even the main causal agent of Alzheimers!<p>In general, if you see someone touting a low effort, pre-clinical study as major medical breakthrough, start hitting the downvote button. I'm disappointed this even got to the main page.
article is a value-added summary of:
<a href="https://www.sciencedaily.com/releases/2016/06/160629095609.htm" rel="nofollow">https://www.sciencedaily.com/releases/2016/06/160629095609.h...</a><p>which is based on this press release:
<a href="http://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/" rel="nofollow">http://www.salk.edu/news-release/cannabinoids-remove-plaque-...</a><p>original paper here:
<a href="https://www.nature.com/articles/npjamd201612" rel="nofollow">https://www.nature.com/articles/npjamd201612</a>
"Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids"<p>original paper:
<a href="https://www.nature.com/articles/npjamd201612.pdf" rel="nofollow">https://www.nature.com/articles/npjamd201612.pdf</a>
Hmm, seems like it's time to seriously consider extracting some THC and CBD. I'm looking at this: <a href="https://magicalbutter.com/" rel="nofollow">https://magicalbutter.com/</a>. Anyone have some experience with this type of gear?
A very exciting petri dish result! If this actually works in an animal model, it could be a true breakthrough. I am wondering if THC <i>in vivo</i> might undergo some kind of subtle metabolism after being ingested or smoked so that it still binds to cannaboid receptors, but doesn't affect beta amyloid.
Marijuana seems to be approaching the peak of inflated expectations of the Hype Cycle <a href="https://en.wikipedia.org/wiki/Hype_cycle" rel="nofollow">https://en.wikipedia.org/wiki/Hype_cycle</a>. Pretty much nothing can't be healed by smoking weed. Let's hope it soon goes back to normalcy.