This was Dr David Sinclair, trying to convince us - again - that he found the fountain of youth, much like he did back in in 2004 with resveratrol, cashing 720m USD after selling his company to Glaxo in 2008.<p>He was later involved [1] in a case of research fraud involving resveratrol.<p>Snake oil I would say.<p>[1] <a href="http://retractionwatch.com/2012/01/12/so-how-peripheral-was-dipak-das-resveratrol-work-really/" rel="nofollow">http://retractionwatch.com/2012/01/12/so-how-peripheral-was-...</a>
My humble opinion is that the cure for aging is going to involve creating some perfect stem cells for the body to regenerate from. The idea is that you could perform an analysis on a few thousand cells from an adult, and since the mutations in each adult cell are in different places, by looking at the most common variant of each base pair you can figure out what the perfect original dna strand looked like. Then you can create at least one perfect stem cell. The reason I like this approach is that fixing mutations by comparing multiple dna strands is something that evolution can’t do, whereas if the problem was some simple chemical that the body needed, evolution would have solved that problem on its own. So I’m gonna go out on a limb and say that’s probably not going to work.
The only human study providing a compelling reason to try nicotinamide riboside is the one showing a drop in blood pressure in hypertensive adults [1]. But this was a very small group of patients. If it does that in most people (which it may not) then that alone is a compelling reason to use it providing the price is low.<p>However, it isn't a compelling reason for the sizable expense of developing this outgrowth of sirtuin / calorie restriction research. That funding and person-years of researcher time could have gone towards far more effective programs such as senolytic development, or other SENS damage repair approaches to aging.<p>Not all NAD+ precursors are the same. The evidence in animal studies suggests that some (such as nicotinamide [2]) do basically nothing. The most effective approaches appear to be infusions, but they are not cheap.<p>Currently nicotinamide riboside is produced by one company in the US, and the retail price reflects that. If you do decide to take it for the long term at the dosage from the studies of 1g/day or so, it is considerably cheaper to order by the kilogram from Chinese manufacturers (plenty of manufacturers on Alibaba) and run the necessary mass spectrometry and other tests per batch to ensure quality (plenty of providers on Science Exchange).<p>While you are taking it, consider that this is small potatoes. It is a tiny effect in the grand scheme of things. Exercise has a larger and more reliable outcome. The research community should be doing better than this (and is in the case of senolytics) and people outside the research community need to become better at telling the difference between marginal and useful approaches to the challenge of aging.<p>[1]: <a href="https://doi.org/10.1038/s41467-018-03421-7" rel="nofollow">https://doi.org/10.1038/s41467-018-03421-7</a><p>[2]: <a href="https://doi.org/10.1016/j.cmet.2018.02.001" rel="nofollow">https://doi.org/10.1016/j.cmet.2018.02.001</a>
Dr Peter Attia did a podcast with Dr Sinclair not too lon ago where they discuss this:<p><a href="https://peterattiamd.com/davidsinclair/" rel="nofollow">https://peterattiamd.com/davidsinclair/</a><p>The show notes on the episodes are always really good, and you can almost read them without listening to the episode.
Here's a link from FDA recognizing that it is safe to use: <a href="https://www.fda.gov/downloads/Food/GRAS/ucm505226.pdf" rel="nofollow">https://www.fda.gov/downloads/Food/GRAS/ucm505226.pdf</a>
For those already taking this what is your daily dosage and do you split it into an Am an Pm schedule? Because if the cost just wondering if people are taking the 1g a day like the article or less (more?).
This article proposes raising levels of NAD to counter aging related dna damage.<p>My google search also resulted in: <a href="https://medicalxpress.com/news/2016-12-pathway-linked-slower-aging-fuels.html" rel="nofollow">https://medicalxpress.com/news/2016-12-pathway-linked-slower...</a><p>TLDR; NAD+ over-activeness is associated with a deadly form of brain cancer, and the article ends with an open question from an expert if it could be modulated to not have this adverse effect.<p>The next step is probably figuring out the tricky balance between these two ends.
Is it possible that NAD would also repair DNA damage in cancer cells? This reminds me of those that take growth hormone in middle age with the hope that cancer will be cured before they get it.
Why are there NMN supplements, when it is essentially vitamin-b / niacin? Honest question, what am I missing?<p>Asking because I already get too much vitamin b3, 6 and 12 from energy drinks.
This is very legit. The results are tremendous. I recommend it to anyone, but with a doctor's recommendation of course.<p>Here is a study on adult humans:
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876407/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876407/</a><p>Edit: Comment edited.
Off-topic, I wonder if other people also subvocalize when reading and then get startled by passages like "already known for its role as a controller."