Well, you can streamline & integrate an entire office's financial, scientific, engineering, marketing, sales, recordkeeping, paperwork, HR, and internal communication and it can be done with the utmost security & reliability when there is no wireless and no connection to the web whatsoever.
Heavyweight media creation applications; eg. Blender/ZBrush, Substance Designer/Painter, Avid MC, ProTools, Adobe Premier/AfterEffects, UE4 Editor.<p>I always get a chuckle out of web programmers who think that because they can do their entire job out of a few web apps, that everyone else can too.