TE
TechEcho
Home24h TopNewestBestAskShowJobs
GitHubTwitter
Home

TechEcho

A tech news platform built with Next.js, providing global tech news and discussions.

GitHubTwitter

Home

HomeNewestBestAskShowJobs

Resources

HackerNews APIOriginal HackerNewsNext.js

© 2025 TechEcho. All rights reserved.

Coronavirus Spike Protein Binder Design

176 pointsby jbjabout 5 years ago

11 comments

natchabout 5 years ago
Strange site. The heading implies that they are attempting to design things that help science, but if you drill in to the pages for &quot;new to fold.it&quot; and FAQ, it never actually says that any of the results are used by anyone. Instead it says that it&#x27;s all a game and the only science goal is to prove that humans are capable (just like computers) of doing this.<p>I wonder if this is really all it is, or if the writers of the FAQ are just myopic about the fact that newcomers don&#x27;t have the big picture, so they just forget to mention whether the results are ever used or not, or even potentially used, or even potentially looked at by anyone who might use them.<p>Reminds me of how a lot of open source packages, when you go to their about page, just have a list of recent updates in highly technical language that assumes the reader is already familiar with the goals of the project.<p>Sites should not assume that the reader already knows what is going on. In this case, the &quot;new to fold.it&quot; page is just a bunch of steps for getting started, with absolutely no overview that makes clear how any of it is all used. Under &quot;goals&quot; the stated science goal is just to prove that humans can solve this kind of puzzles. Really odd that teams would give time to this if it&#x27;s not having any real effect though, so I suspect I&#x27;m missing something?
评论 #22475551 未加载
评论 #22481325 未加载
评论 #22477838 未加载
hditorkeifabout 5 years ago
This is what antibodies do, right?<p>How exactly does the body figure out how to configure the variable part of the antibody so that it binds? Does it just try countless variations until it finds a match?<p>Can we take an antibody from a healed person and reverse engineer the binding protein?
评论 #22475802 未加载
评论 #22474099 未加载
评论 #22474330 未加载
评论 #22476333 未加载
Aissenabout 5 years ago
I know it&#x27;s fun, and I think participative science is such a huge shift in paradigm … But considering the global impact of coronavirus, I&#x27;m wondering if there shouldn&#x27;t be a better way to fund this type of endeavor.<p>Any cloud provider willing to donate compute to researchers?
评论 #22473796 未加载
评论 #22473152 未加载
评论 #22473755 未加载
评论 #22474716 未加载
评论 #22473117 未加载
DrAwdeOccarimabout 5 years ago
There is already stuff like this out there: <a href="https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2020.02.01.929976v2.full.pdf" rel="nofollow">https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2020.02.01.929976v2....</a><p>Also, it appears as though convalescence therapy is working (i.e., treating people with the plasma from recovered patients) <a href="https:&#x2F;&#x2F;www.straitstimes.com&#x2F;asia&#x2F;east-asia&#x2F;china-seeks-plasma-from-recovered-patients-as-coronavirus-treatment" rel="nofollow">https:&#x2F;&#x2F;www.straitstimes.com&#x2F;asia&#x2F;east-asia&#x2F;china-seeks-plas...</a> <a href="https:&#x2F;&#x2F;news.yahoo.com&#x2F;chinese-doctors-using-plasma-therapy-161924314.html" rel="nofollow">https:&#x2F;&#x2F;news.yahoo.com&#x2F;chinese-doctors-using-plasma-therapy-...</a>
评论 #22474541 未加载
ameliusabout 5 years ago
If you find a protein that blocks the virus, how difficult would it be to find a drug delivery mechanism that is capable of reaching all the important cells?
评论 #22473331 未加载
评论 #22475471 未加载
cbg0about 5 years ago
Mirror: <a href="http:&#x2F;&#x2F;archive.is&#x2F;y67Ig" rel="nofollow">http:&#x2F;&#x2F;archive.is&#x2F;y67Ig</a>
zedrabout 5 years ago
Fascinating... What are the odds against finding this particular type of antagonist protein?
评论 #22475891 未加载
nednarabout 5 years ago
If there are people with expert knowledge here, can you explain how people heal from such kind of virus (or in general) if there are no counter measures external to the infected human?<p>I&#x27;m a little confused about how it works with virus vs bacteria.
评论 #22476361 未加载
hktabout 5 years ago
HN hug of death?
评论 #22473917 未加载
评论 #22473642 未加载
mkchoi212about 5 years ago
Noob question but what&#x27;s the incentive behind people trying to solve puzzles on this site?? Other than glory and fame of course :p
dmdabout 5 years ago
There&#x27;s a Greg Egan short story &quot;Zero For Conduct&quot; that&#x27;s about this kind of site.