TE
TechEcho
Home24h TopNewestBestAskShowJobs
GitHubTwitter
Home

TechEcho

A tech news platform built with Next.js, providing global tech news and discussions.

GitHubTwitter

Home

HomeNewestBestAskShowJobs

Resources

HackerNews APIOriginal HackerNewsNext.js

© 2025 TechEcho. All rights reserved.

Camostat and E-64d need to be fast-tracked for clinical trials

7 pointsby forkexecabout 5 years ago
These two compounds together form a synergistic blockade of the ability of SARS-CoV-2 to invade human cells (prophylaxis; per the paper in the Cell journal). If side-effects can be rapidly identified and minimal, it could be good bridge until a vaccine is developed (2 years+, high probability of yearly&#x2F;semi-annual recurrent epidemics).<p>Camostat Mesylate &#x2F; Camostat &#x2F; 59721-29-8<p>- 100-200 mg p.c. (300-600 mg&#x2F;daily)<p>- Used in Japan for postoperative reflux esophagitis &amp; acute chronic pancreatitis<p>E-64d &#x2F; Aloxistatin &#x2F; Loxistatin &#x2F; EP-453 &#x2F; 88321-09-9<p>- Possibly 100-150 mg p.c. (300-450mg&#x2F;daily)<p>- May increase risk of bleeding &#x2F; bleeding strokes &#x2F; reduce clotting &#x2F; thin the blood<p>- Prices of this compound are currently very high but would hopefully reduce with scale and local synthesis

no comments

no comments