So nutritionally we should be looking at things needed to stimulate the NOS gene (NOS1, NOS2, NOS3):<p>NOS2 cofactors are; Heme, FAD, FMN, and BH4<p>Zinc - It helps make BH4 through the GCH1 and PTS enzymes from GTP.<p>Riboflavin - it is the precursor for FMN and FAD. Notably zinc is needed to turn riboflavin into FMD and FAD.<p>B6 (P5P) - Needed for Heme synthesis.<p>Beets - The nitrates are turned into NO in the gut.<p>Black Tea - Shown to increase NO. And shown to inhibit SARS: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142193/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142193/</a><p>Vitamin C - Helps protect BH4<p>But it is for certain another reason to examine zinc in health outcomes from SARS infection. The metal binding site of NOS is zinc also so...
Also, nitric oxdide is necessary for erections, and is what all the "boner drugs" increase when used.<p><a href="https://www.mayoclinic.org/diseases-conditions/erectile-dysfunction/diagnosis-treatment/drc-20355782" rel="nofollow">https://www.mayoclinic.org/diseases-conditions/erectile-dysf...</a><p><pre><code> Sildenafil (Viagra)
Tadalafil (Adcirca, Cialis)
Vardenafil (Levitra, Staxyn)
Avanafil (Stendra)
</code></pre>
Just wait for the spammers to get word of this. The emails should be entertaining: "Huge boner and kill COVID! BUY HERE!!!1!!"
There have been a bunch of posts about this, including this paper, on <a href="https://www.reddit.com/r/covid19stack" rel="nofollow">https://www.reddit.com/r/covid19stack</a>. E.g. here is an interesting post with a bunch of natural breathing techniques for boosting nitric oxide production:<p><a href="https://www.reddit.com/r/covid19stack/comments/fp3i6l/naturally_produced_nitric_oxide_may_boost/" rel="nofollow">https://www.reddit.com/r/covid19stack/comments/fp3i6l/natura...</a><p>There are a bunch of YouTube videos demonstrating how to do it if you search for them. The FDA also recently granted compassionate use authorization to a device that produces inhaled nitric oxide:<p><a href="https://www.fiercebiotech.com/medtech/fda-expands-access-to-bellerophon-s-nitric-oxide-gas-for-covid-19-lung-symptoms" rel="nofollow">https://www.fiercebiotech.com/medtech/fda-expands-access-to-...</a><p>This is a great example of why people don't trust mainstream medicine. You have the WHO very publicly "debunking" the idea that garlic could prevent Covid-19, and then the FDA approves use of some multi-million dollar device with the same mechanism of action and the company's stock increases 5x in a day.
Exposure to NOx can also permanently reduce lung function. This is one of those “in vitrio” things that’s kind of interesting but probably ultimately unhelpful (at least for the current situation.)
So no harm including beets, beet juice, or beet root powder in your routine. Might even help. <a href="https://www.ahajournals.org/doi/full/10.1161/hypertensionaha.107.103523" rel="nofollow">https://www.ahajournals.org/doi/full/10.1161/hypertensionaha...</a>
If true this N.O. theory could explain some of the dramatic differences in Covid 19 outcomes based on age.<p>"...production of NO declines steadily with increasing age..."
(<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390088/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390088/</a>)<p>It could also explain why heart disease, diabetes, and high blood pressure are comorbid for Covid 19 as they are all associated with lower N.O.
I wonder if we're in danger of p hacking here. Suppose in the scramble to contain the outbreak, <i>everything</i> is tested for efficacy against the disease. There will surely be some positive studies just due to luck.
Coincidence?<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939908/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939908/</a><p>Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes
So, does use of nicotine cause nitric oxide to be released in the body?<p>Was there some anecdotal data related to smoking and infection rate?<p>I know very little about biology.