Breakdown by David Sinclair in this Twitter thread: <a href="https://twitter.com/davidasinclair/status/1259912928695857152" rel="nofollow">https://twitter.com/davidasinclair/status/125991292869585715...</a><p>Highlight:<p>><i>The result is so literally incredible that even the first author, Prof. Steve Horvath, didn't believe it at first. I suggested he check if the rats were mixed up, but he assured me he checked their genomes. The rats weren't mixed up and the data is the data. </i><p>><i>Using the final versions of their epigenetic clocks the reversal was: liver 75%, blood 66%, heart 57%, hypothalamus 19%. Average rejuvenation across four tissues was 54.2%. This is astounding.</i><p>><i>What else did they see? Accumulation of fat in old tissues was greatly reduced. All health-related blood biomarkers they assessed (lipids, liver function, blood cells) "were altered towards the values of young rats, without exception."</i>