So no info on what it actually is. Just some company filing a patent. And the fact that they call it "a neutralizer technology" suggests that it's probably just a bunch of BS combined with previously known drugs to make it patentable.<p>I'm pretty sure there's at least some published research on using at least one antipsychotic for that and mountains of "folk research" on using benzodiazepines.
Any competitive 5-HT2A antagonist will block psychedelic effects from classical psychedelic drugs, and D2 antagonists will block the potential for stimulant-esque psychosis that drugs like LSD can trigger through dopamine agonism.<p>There are probably hundreds of drugs that fall into these classes, and many of them have significant clinical data to derive their safety profiles from.<p>If someone comes into a hospital with a bad reaction to psychedelic drugs, it's not uncommon for them to be given something like risperidone, both a 5-HT2A and D2 antagonist, and an anxiolytic to calm them down.
>LSD has been classified in the vast majority of countries as a Schedule 1 illegal drug for more than 50 years, ever since the adoption of the United Nations' Convention on Psychotropic Substances.<p>>That scheduling means regulators believe the drug has "no currently accepted medical use" — and according to scientists from Imperial College London's Centre for Psychedelic Research, it's had a hugely negative impact on LSD research.<p>The US fucked up a lot of research forcing other countries to sign that convention.
People regularly use Trazodone [1] as a trip killer. I personally haven't and I don't like using them, but it does its job pretty well from what I've heard.<p>[1] <a href="https://en.wikipedia.org/wiki/Trazodone" rel="nofollow">https://en.wikipedia.org/wiki/Trazodone</a>
Wow. So basically they re-invented Xanax? :P<p>Joking aside, No way there is any chance that you would stick this in a human (huge potential for harm, no real clinical use case).<p>LSD is an insanely potent 5HT agonist, it seems highly unlikely any drug that is not "serious" would cause any significant reduction in LSD effects. Benzo's like Xanax can make the trip go in a direction that is less negative... but you are still tripping balls.
On a related note, lavender oil and theanine have recently been (preliminarily) shown to increase the likelihood of a good trip: <a href="https://www.reddit.com/r/shrooms/comments/gwh87x/scientific_revelations_about_what_causes_good_and/" rel="nofollow">https://www.reddit.com/r/shrooms/comments/gwh87x/scientific_...</a><p>which references this article: <a href="https://www.nature.com/articles/s41386-020-0718-8" rel="nofollow">https://www.nature.com/articles/s41386-020-0718-8</a>
They aren't being clear on what they are doing exactly but Why not just use Ketanserin. It's what they have been using on mice for a while now .
note: i’m not a doctor or anything related.<p>Wikipedia says “5-HT2A antagonists block the psychedelic activity of LSD”[0], so wouldn’t 5-ht2a antagonists like mirtazapine work well enough here?<p>No idea as to how quickly the trip would be tempered, though<p>[0]: <a href="https://en.m.wikipedia.org/wiki/Lysergic_acid_diethylamide" rel="nofollow">https://en.m.wikipedia.org/wiki/Lysergic_acid_diethylamide</a>