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Feline coronavirus drugs inhibit SARS-CoV-2 main protease

12 pointsby sapsanover 4 years ago

1 comment

phobosanomalyover 4 years ago
From what I can tell GC376 is preclinical in cats, but it&#x27;s been around for a while?<p>&quot;When given to younger kittens, GC376 interfered with the development of permanent teeth.&quot;<p><a href="https:&#x2F;&#x2F;www.avma.org&#x2F;javma-news&#x2F;2020-01-15&#x2F;fip-drugs-continue-show-promise-while-being-sold-black-market" rel="nofollow">https:&#x2F;&#x2F;www.avma.org&#x2F;javma-news&#x2F;2020-01-15&#x2F;fip-drugs-continu...</a><p>A subsequent compound was developed called GS-441524 that showed greater efficacy, and has been making its way out of the Chinese black market to desperate cat owners, which vets aren&#x27;t thrilled about.<p><a href="https:&#x2F;&#x2F;ccah.vetmed.ucdavis.edu&#x2F;cats&#x2F;resources&#x2F;general-feline-infectious-peritonitis-resources" rel="nofollow">https:&#x2F;&#x2F;ccah.vetmed.ucdavis.edu&#x2F;cats&#x2F;resources&#x2F;general-felin...</a><p>I smell the next hydroxychloroquine with a future run on black-market Chinese GS-441524.<p>Edit: From Wikipedia - &quot;The public health advocacy group, Public Citizen, in an open letter urged the DHHS and Gilead to investigate GS-441524 for the treatment of COVID-19, suggesting that GILEAD was not doing so for financial motives related to the longer intellectual property lifespan of Remdesivir.&quot;