Did they synthetize the DNA in their kitchen, or they paid an specialized lab to do that part?<p>> <i>To date this is by far the largest dosage(10mg) of a DNA plasmid based gene therapy outside a clinical trial(all others have been in micrograms or single milligrams).</i><p>Why? Is there any indication that a big dose is more effective?<p>Luckily they had no big side effects, but any test of a candidate of a vaccine has a chance of a problem. That's why they are tested firs in very small groups and under medical supervision.<p>A few days ago, the Pfizer vaccine caused a problem in two persons with an history of allergy problems. It is always a possibility.<p>Also, there is <a href="https://en.wikipedia.org/wiki/Antibody-dependent_enhancement" rel="nofollow">https://en.wikipedia.org/wiki/Antibody-dependent_enhancement</a> that has been observed in coronavirus.<p>The clinical test for a vaccine are very important.