TE
TechEcho
Home24h TopNewestBestAskShowJobs
GitHubTwitter
Home

TechEcho

A tech news platform built with Next.js, providing global tech news and discussions.

GitHubTwitter

Home

HomeNewestBestAskShowJobs

Resources

HackerNews APIOriginal HackerNewsNext.js

© 2025 TechEcho. All rights reserved.

Gam-COVID-Vac phase 3 trial results: 91·6% efficacy and well tolerated

102 pointsby zhan_egover 4 years ago

10 comments

bhaavanover 4 years ago
91.6% is a good efficacy. Do they have plans to test it against other variants (E501Y mutation)? Ideally this + the adenovirus based AZD122 seems to be the best combination of (efficacy, affordablility, and logistically feasibility) end for the pandemic. <a href="https:&#x2F;&#x2F;www.gavi.org&#x2F;vaccineswork&#x2F;coronavirus-why-combining-oxford-vaccine-russias-sputnik-v-vaccine-could-make-it" rel="nofollow">https:&#x2F;&#x2F;www.gavi.org&#x2F;vaccineswork&#x2F;coronavirus-why-combining-...</a> is another such article which talks about it.
sradmanover 4 years ago
The Russian Sputnik V vaccine [1] distinguishes itself from other two-dose Adenovirus vector vaccines [2] (Oxford–AstraZeneca and Chinese CanSino) by using different vectors (Ad26 and Ad5) for each dose. The Johnson &amp; Johnson vaccine [3] is an Ad26 single-vector single-dose vaccine.<p>In my opinion, the outstanding question is production capacity. Given the supply chains and geopolitics involved, I think the rational choice is to get whatever approved vaccine is available to you as soon as possible.<p>[1] <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Sputnik_V_COVID-19_vaccine" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Sputnik_V_COVID-19_vaccine</a><p>[2] <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;COVID-19_vaccine#Adenovirus_vector_vaccines" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;COVID-19_vaccine#Adenovirus_ve...</a><p>[3] <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Ad26.COV2.S" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Ad26.COV2.S</a>
inglorover 4 years ago
91.6% seems like a very good result for this vaccine and a big confidence boost to the companies that bought it.<p>I&#x27;m waiting for the J&amp;J results after two-dose immunisation given this vaccine takes a similar (non mRNA) approach and appears to be very effective.<p>(Not ignoring that 66% efficiency is still significant but much less so than 91.6%)
评论 #26001536 未加载
评论 #26005110 未加载
评论 #26001699 未加载
boringgover 4 years ago
Does the funding source have some bias impacts in this kind of thing? (i.e.: Moscow City Health Department, Russian Direct Investment Fund, Sberbank, and RUSAL.)
Ulrich2over 4 years ago
Can this phase3 data be trusted? Is the raw data available for screening&#x2F;checking, or do we have only the publication?
评论 #26002070 未加载
评论 #26002290 未加载
puzzlingcaptchaover 4 years ago
I wonder how much the heterologous approach (different viral vectors for first and second doses) contributed to its high efficiency compared to a similar Astra Zeneca vaccine. Conversely, why did Astra Zeneca opted not to do it this way.
评论 #26002030 未加载
throwaway4goodover 4 years ago
European authorities need to approve this ASAP.
mrtksnover 4 years ago
I have been asking this the last week, only to receive downvotes and no proper answers: Why EU&#x2F;UK&#x2F;USA did not even consider the Russian and Chinese vaccines?<p>They all can go &quot;realpolitik&quot; but have their economies crushed and citizens lost for the sake of political rivalry then fight with each other who gets the Western vaccines first?<p>I&#x27;m sorry for asking it, I get that you don&#x27;t like the question but I feel like it is a fair question. I&#x27;m not deleting this.
评论 #26001922 未加载
评论 #26002033 未加载
评论 #26001792 未加载
评论 #26008561 未加载
评论 #26002552 未加载
评论 #26001811 未加载
评论 #26001914 未加载
mchusmaover 4 years ago
I doubt the US will see much of this, but this is now one of at least 4 high quality vaccines with great, public data banned from use in the US:<p>Astrazeneca, J&amp;J, Novavax, and Sputnik V.
评论 #26001975 未加载
评论 #26003535 未加载
nullifidianover 4 years ago
It&#x27;s all nice and good, but Putin made this vaccine&#x27;s effectiveness a political issue. If it&#x27;s significantly less effective than its western counterparts it would result in a severe loss of face for Putin&#x27;s propagandists and the regime in general. Considering the historical record of Putin&#x27;s regime love for truth and integrity, it wouldn&#x27;t be surprising if many people would choose to take these results with a grain of salt.
评论 #26002453 未加载