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Is skipping J&J and waiting (a little while) for Pfizer/Moderna wiser?

2 pointsby pardnerabout 4 years ago
It seems to me that the official recommendation &quot;the best vaccine is the one they offer you first&quot; ignores one crucial consideration that might make a better decision for some individuals to be &quot;skip the J&amp;J <i>if</i> I can get Pfizer&#x2F;Moderna by waiting a &#x27;reasonably short&#x27; time&quot;.<p>That crucial consideration is: the health of un-vaccinated people around me. If there are people around me who will not be eligible for a vaccine for months, THEY seem to be better protected - from me - if I choose either of the two higher-efficacy vaccines (within a &quot;reasonably short&quot; incremental timeframe).<p>Based on the data we have so far it looks like I am about 5x more likely to get infected after J&amp;J compared to Pfizer&#x2F;Moderna, based on J&amp;J&#x27;s lower efficacy of about 75% vs 95%.<p>Even though J&amp;J would protect ME from serious complications, if I get J&amp;J and then get infected I am contagious, and therefore I am a risk to still-unvaccinated people around to me who still have normal risk for serious&#x2F;fatal complication.<p>So if I can expect to have Moderna or Pfizer available within a &quot;reasonably short&quot; time frame, I&#x27;ll wait for one of those higher-efficacy vaccines in order to better ALSO protect the unvaccinated people around me.<p>But the hard part is deciding what is a &quot;reasonably short&quot; timeframe? There is obviously a non-zero incremental risk from waiting, so that short-term risk (to me and mine) needs to be balanced against the longer-term risk (to others) from my rushing to accept a less efficacious vaccine sooner.<p>Using the current daily covid infection rate divided by the population as a rough, quick, back-of-envelope guesstimate for &quot;incremental daily risk of infection&quot; on the order of 0.015%.<p>Pretty big assumptions. But unless my reasoning is way off, I&#x27;ll be willing to wait an extra 10-14 days for Pfizer&#x2F;Moderna (vs J&amp;J) with the goal of lower net risk to the unvaccinated people around me.

1 comment

geophileabout 4 years ago
The efficacy rates are not comparable. My understanding is that, compared to the Moderna and Pfizer vaccines, J&amp;J was tested on a more diverse population with respect to age and location, and also tested later, so that it faced more variants of the virus.<p>Get whatever vaccine you can.<p>(Disclaimer: I got the J&amp;J vaccine two weeks ago.)
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