From the Nature article:<p>"Peak antibody levels were 3.5 times higher in those who waited 12 weeks for their booster shot than were those in people who waited only 3 weeks. Peak T-cell response was lower in those with the extended interval. But this did not cause antibody levels to decline more quickly over the nine weeks after the booster shot."<p>I care less about short-term peak antibody response than longer-term T-cell response or longest-term immunizing antibody response. On the latter two points, this study was not encouraging or outright silent. Nor was there any indication of how well these folks fared after they returned to the wild.<p>This info doesn't seem sufficient to draw meaningful conclusions about longer term protection.
Can't help but feel the UK had incredible luck on their side here. Being in the UK I'm thankful it played out well...but wow...talk about a roll of the dice.<p>(As best as I know there was little scientific evidence available when they decided to delay)
This story back in February reported 'Single Pfizer shot 90 percent effective after 21 days' and that 'vaccine effectiveness was still pretty much zero until about 14 days after people were vaccinated. But then after day 14 immunity rose gradually day by day to about 90 percent at day 21....' [<a href="https://medicalxpress.com/news/2021-02-pfizer-shot-percent-effective-days.html" rel="nofollow">https://medicalxpress.com/news/2021-02-pfizer-shot-percent-e...</a>]<p>This looks to fit in with that trend ... after 14 days, slowly growing immunity.
I just had a conversation with a doctor. She mentioned her clinical team thinks that if you had COVID recently you should wait 3 to 4 months before getting vaccinated. The reason being because your immune system is messed up. Any doctors or immunologists here that can comment on this advice ?
Great. My local health clinic auto-booked my next appointment (despite telling me I had to do it) just inside 3 weeks from my first shot. I think they're a little worried about people coming back for their second shot.
> For the United Kingdom, extending the interval between doses was clearly the right choice, but the country’s lockdown deserves part of the credit for that success<p>This is important for anyone who thinks it might be a good idea to wait. You have to carefully weigh the risk of being vulnerable in the meantime.