I am a structural biologist studying Archaeal viruses and CRISPR/Cas proteins. From my point of view, AlphaFold has basically just gotten better at multiple sequence alignments. It's not a bad thing, but it's unfortunate useless to me because sequence divergence happens so quickly in the organisms I study that even the best results are still basically made up. It's nice that AlphaFold got better at generating sequence alignments, but it's not a magic bullet (a la folding figured out from first principles.)<p>Interestingly enough, if I get experimental data of an archeal virus protein, it almost always uses a conserved fold. There's just no evidence at the amino acid level.
Is there nothing 'new' that this cutting edge technology can be used for that allows fast iterations given the limitless folds or whatever is available. Ie. Not homosapien medicine.<p>Look for your keys where the light is shinning, not in the dark.