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Delta variant will acquire complete resistance to wild-type spike vaccines

52 pointsby jpdusover 3 years ago

5 comments

criticaltinkerover 3 years ago
Some highlights from my notes on the OP [1]:<p><i>&gt; All anti-NTD neutralizing antibodies failed to recognize the Delta spike, indicating that the Delta variant is completely resistant to anti-NTD neutralizing antibodies elicited by wild-type spike protein, which is the antigenic component of widely used mRNA vaccines.</i><p><i>&gt; A third round of booster immunization with the SARS-CoV-2 vaccine is currently under consideration. Our data suggest that repeated immunization with the wild-type spike may not be effective in controlling the newly emerging Delta variants. </i><p>[1] The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines <a href="https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2021.08.22.457114v1" rel="nofollow">https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2021.08.22.457114v1</a>
teoremaover 3 years ago
Whatever happened to the idea that boosters would be tailored to currently circulating virus variants, ala flu vaccines? Somewhere along the way the policy discussion shifted and I don&#x27;t know why.<p>I&#x27;m becoming increasingly infuriated with the FDA and CDC.
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trdtaylor1over 3 years ago
Per article,<p>Delta remains handled by current mRNA. Combine 4 seen mutations (present in Delta+) and it has complete breakthrough.
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doomroboover 3 years ago
Part of this research was inducing specific mutations in their samples and testing infectivity. Is that what people mean by Gain of Function research?
jleyankover 3 years ago
Change&#x2F;expand the payload of the mRNA vaccines as appropriate: <a href="https:&#x2F;&#x2F;fortune.com&#x2F;2021&#x2F;08&#x2F;09&#x2F;covid-vaccines-delta-variant-vaccine-biontech-pfizer&#x2F;" rel="nofollow">https:&#x2F;&#x2F;fortune.com&#x2F;2021&#x2F;08&#x2F;09&#x2F;covid-vaccines-delta-variant-...</a>