Interestingly, some patients during the TRIIM trial (thymus rejuvenation by application of human growth hormone and metformin) had their hair turning dark again, though they were a minority. A new trial, TRIIM-X, is now underway, and the researches actually took photos of all the participants at the beginning in order to be able to capture potential changes in appearance.<p><a href="https://www.lifespan.io/news/lifextenshow-thymic-rejuvenation/" rel="nofollow">https://www.lifespan.io/news/lifextenshow-thymic-rejuvenatio...</a><p>So the part about the immune system possibly mistakenly killing the melanocytes might be right.<p>But the statement<p>"Aging is made up of a bunch of different systems: aging of the skin, the heart, the brain, the immune system."<p>strikes me as unsupported. It is entirely possible that all those processes, though superficially very different from one another, may have ony one or two or three common roots.
There's a twin problem to reversing graying: reversing bolding. And there are solutions to it that work, the newest is finasteride. The only problem with it is that it causes impotance in 1% of the people. As it doesn't affect lifespan, getting an anti-graying solution through the FDA process takes billions of dollars and even then they can have long term sife effects that make them not worth to take.<p>Curing the 7 known underlying causes of aging one by one and showing differences in serious illnesses have the option to give feedback already in Phase 1 on humans, the less expensive part of the approval process.
While complex, greying hair seems like a finite and solvable problem given enough time. Build a large enough genome database, exhaustive studies for hormone balances, and do the science…it feels “treatable”.<p>Where as wholesale aging and solving for aging in general will be a totally other monster that never gets fully solved just partially treated. Extensions of healthy life and total lifetime seem fairly likely while “Freezing” aging is likely impossible.<p>Interesting that corticosteroids had that effect, as well as all of the other methodologies.<p>Feels like an underexplored avenue for comprehensive studies/research