10 Tips For Creating Website Mockups In Photoshop

I don't think there's anything wrong with the "hybrid" approach. Obviously, some things take a lot longer to do in CSS/XHTML, so Photoshop is the best tool to use when brainstorming or comping for a client. But at some point it can become counterproductive trying to replicate all browser behavior in Photoshop, so I just "run with it" and deal with the detail in CSS/XHTML.

0. Do not mock up webpages in Photoshop.

I use Photoshop as my thinking tool. Designers think too, not just programmers. Designers don't just make things look pretty.