Pfizer no longer have trust. For anything. Just read the documents they were forced to release this year (rather than 75 years in the future) - you figure out pretty quick why they wanted it covered up for 75 years. It's horrific.
'Hacking' an intravenous drug to make it work as an oral drug: <i>One key part of the chemists’ strategy was to eliminate some of the hydrogen bond donors that keep PF-00835231 in the gut. If a particular hydrogen bond is critical to making the compound bind to the protease, it had to stay in the molecule. “We were looking for hydrogen bonds that we could get rid of without losing antiviral potency.”</i>