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Study: Curcumin spice boosts memory by 30%, eases depression

36 pointsby Cenkalmost 3 years ago

12 comments

throckmortraalmost 3 years ago
What is up with all the alt-medicine spam on HN?<p><a href="https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC5346970&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC5346970&#x2F;</a><p>&quot;The likely false activity of curcumin in vitro and in vivo has resulted in &gt;120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful.&quot;
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eganistalmost 3 years ago
Notable: no direct reference to &quot;conflict&quot; or related terms in the original paper, but the conflict statement comes at the end of the discussion:<p>&gt; The University of California, Los Angeles, owns a U.S. patent (6,274,119) entitled “Methods for Labeling ß-Amyloid Plaques and Neurofibrillary Tangles”, which has been licensed to TauMark, LLC. Drs. Small, Satyamurthy, Huang, and Barrio are among the inventors and have financial interest in TauMark, LLC. Dr. Small also reports having served as an advisor to and&#x2F;or having received lecture fees from Allergan, Argentum, Axovant, Cogniciti, Forum Pharmaceuticals, Herbalife, Janssen, Lundbeck, Lilly, Novartis, Otsuka, and Pfizer. Dr. Heber reports receiving consulting fees from Herbalife, and the McCormick Science Institute. <i>The manufacturer of Theracurmin, Theravalues Corporation, provided the Theracurmin and placebo for the trial, funds for laboratory testing of blood curcumin levels, and funds for Dr. Small&#x27;s travel to the 2017 Alzheimer&#x27;s Association International Conference for presentation of the findings.</i><p>They saved the worst conflict for last, of course. This paper earns a pretty easy Flag.
Zababaalmost 3 years ago
&gt; In an 18 month, placebo-controlled study with 40 subjects (age 51–84 years), researchers found that 90mg of curcumin twice a day improved outcomes of verbal, visual, and attention test scores by 28%.<p>&gt; Dr. Gary Small of the Longevity Center at the University of California and a team of 15 other scientists tested the compound on 40 adults aged between 51 and 84, all of whom had mild memory problems.<p>&gt; For a total of 18 months, the participants were randomized to one of two groups. One group took 90 milligrams of curcumin twice daily, while the other group took a placebo. The curcumin used in this study was a bioavailable form called Theracurmin, which the researchers describe as a “form of curcumin with increased intestinal endothelium penetrability”<p>The highlight here, for me, is the &quot;all of whom had mild memory problems&quot;. In pretty much everything I&#x27;ve seen about cognitive performance improvement, &quot;fixing a problem&quot; is way easier than improving performance. I wouldn&#x27;t expect a 30% boost for patients that don&#x27;t have mild memory problems.
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iknownothowalmost 3 years ago
In that case I would be curious if these differences show themselves in people from different cultures that consume Turmeric en masse. For example, my aging parents consume significant amounts of turmeric (approx. 250 mg) for 2 out of 3 meals every day.
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namlemalmost 3 years ago
The Wiki article suggests it has not performed well in previous trials: <a href="https:&#x2F;&#x2F;en.m.wikipedia.org&#x2F;wiki&#x2F;Curcumin#MedicalResearch" rel="nofollow">https:&#x2F;&#x2F;en.m.wikipedia.org&#x2F;wiki&#x2F;Curcumin#MedicalResearch</a><p>Given that this study produced a very large effect, I suspect a mistake was made somewhere.<p>Edit: this study seems to use a more bioavailable form actually, theracumin<p>I found this review of several studies which suggests that maybe there is something to theracumin<p><a href="https:&#x2F;&#x2F;www.xiahepublishing.com&#x2F;2472-0712&#x2F;ArticleFullText.aspx?sid=2&amp;id=10.14218&#x2F;ERHM.2018.00024" rel="nofollow">https:&#x2F;&#x2F;www.xiahepublishing.com&#x2F;2472-0712&#x2F;ArticleFullText.as...</a>
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insicknessalmost 3 years ago
Examine.com is a great site to summarize and analyze studies on supplements:<p><a href="https:&#x2F;&#x2F;examine.com&#x2F;supplements&#x2F;curcumin&#x2F;" rel="nofollow">https:&#x2F;&#x2F;examine.com&#x2F;supplements&#x2F;curcumin&#x2F;</a>
nehalemalmost 3 years ago
Link to cited study: <a href="https:&#x2F;&#x2F;doi.org&#x2F;10.1016&#x2F;j.jagp.2017.10.010" rel="nofollow">https:&#x2F;&#x2F;doi.org&#x2F;10.1016&#x2F;j.jagp.2017.10.010</a>
beaugundersonalmost 3 years ago
Be careful if you take curcumin and are also taking medication that is metabolized by CYP2D6, as it is a CYP2D6 inhibitor. It will likely increase side effects and the duration of effect for those medications. It still blows my mind that this information is not given out with these medications (as there are other common CYP2D6 and P450 inhibitors with the same effect).
dukeofdoomalmost 3 years ago
Don&#x27;t ever spill this stuff in your kitchen. Nothing quite like it to clean up. Gets into every crevice.
monkellipsealmost 3 years ago
40 subjects.
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marcodiegoalmost 3 years ago
Nice. I look at it later. That is, if I don&#x27;t forget.
AndrewOMartinalmost 3 years ago
But does it make safe and accurate interstellar travel possible?