This article is a bit old (like the other comment about missing year tag says).<p>I think there's newer news that AKG, an easy to get and cheap supplement, has anti-aging effects with no known issues.<p><a href="https://www.science.org/content/article/bodybuilding-supplement-promotes-healthy-aging-and-extends-life-span-least-mice" rel="nofollow">https://www.science.org/content/article/bodybuilding-supplem...</a>
Epigenetics is fascinating. I just came back from a project meeting, where i work with people who discovered that HRT (hormone replacement therapy) slows down epithelial cell aging. Epithelial cells are the cells that cover all your vital organs, so they are important for aging.<p>Now, there are even commercial companies that measure Epigenetic age of cells with a technique called DNA methylation.<p>References:
<a href="https://investinaustria.at/en/news/2022/03/epigenetic-clock-university-of-innsbruck.php" rel="nofollow">https://investinaustria.at/en/news/2022/03/epigenetic-clock-...</a><p><a href="https://www.mydnage.com/?gclid=Cj0KCQjwheyUBhD-ARIsAHJNM-MrkfOmec1lY-Eb-aiITIqCWiKgVvhH0b_FrhcMKEvqIzTd9xj5MA4aAtHPEALw_wcB" rel="nofollow">https://www.mydnage.com/?gclid=Cj0KCQjwheyUBhD-ARIsAHJNM-Mrk...</a>
They're conducting a Phase II trial now with 85 participants, the completion date is set to November 2022.<p><a href="https://clinicaltrials.gov/ct2/show/NCT04375657" rel="nofollow">https://clinicaltrials.gov/ct2/show/NCT04375657</a>
For anyone interested in the topic, I'd encourage reading "Lifespan" by David A. Sinclair. As someone with little to no-knowledge about aging (other than feeling the effects of aging on myself) I found it very instructive on how our aging clock works and what are some of the ongoing studies to slow down or revert aging.
You can do this at home, except for the little inconvenience that growth hormone is a scheduled drug. I wonder what the results would be with just growth hormone. Let's ask Sylvester Stallone[1] who looks great for 75 and got caught trying to get into Australia with illicit Growth Hormone a while ago[2].<p>[1]<a href="https://en.wikipedia.org/wiki/Sylvester_Stallone" rel="nofollow">https://en.wikipedia.org/wiki/Sylvester_Stallone</a><p>[2]<a href="https://abcnews.go.com/Health/ActiveAging/story?id=3176015" rel="nofollow">https://abcnews.go.com/Health/ActiveAging/story?id=3176015</a>
I'll be happy if two things happen:<p>1. I can have "better years" in the same lifespan. Lots of energy at 90 for instance.<p>2. I can increase the lifespan of my dog by 50 years :)
I’m no fan of death, but death (by natural causes - age, sickness , accident) has been how different generations have gotten rid some of the worst despots.
Does anybody know if the East German sportsfolk doped HGH? According to a recent HN post, their lifespan got reduced by around a decade.<p><a href="https://news.ycombinator.com/item?id=31591777" rel="nofollow">https://news.ycombinator.com/item?id=31591777</a>
Believe this was posted on hn before, but this article is in-depth on the current state<p><a href="https://www.adanguyenx.com/blog/partial-reprogramming" rel="nofollow">https://www.adanguyenx.com/blog/partial-reprogramming</a>
I was expecting the article would be about nicotinamide mononucleotide (NMN)[1]. "Lifespan..."[2], a book on the subject, and more recent publications also mention rapamycin[3][4][5] and metformin[6][7][8].<p>[1] <a href="https://en.wikipedia.org/wiki/Nicotinamide_mononucleotide" rel="nofollow">https://en.wikipedia.org/wiki/Nicotinamide_mononucleotide</a><p>[2] <a href="https://en.wikipedia.org/wiki/Lifespan:_Why_We_Age_%E2%80%93_and_Why_We_Don%27t_Have_To" rel="nofollow">https://en.wikipedia.org/wiki/Lifespan:_Why_We_Age_%E2%80%93...</a><p>[3] <a href="https://en.wikipedia.org/wiki/Sirolimus" rel="nofollow">https://en.wikipedia.org/wiki/Sirolimus</a><p>[4] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972801/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972801/</a><p>[5] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/</a><p>[6] <a href="https://en.wikipedia.org/wiki/Metformin" rel="nofollow">https://en.wikipedia.org/wiki/Metformin</a><p>[7] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990352/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990352/</a><p>[8] <a href="https://pubmed.ncbi.nlm.nih.gov/31405774/" rel="nofollow">https://pubmed.ncbi.nlm.nih.gov/31405774/</a>
Did they continue tracking health effects years after they study ? It’s possible the drugs reversed the body clock but will accelerate it after. Much like coffee gives you a temporary boost, then makes you crash later
Before you run out to get some growth hormone, you should be aware that metformin seems to extend health span and life span quite effectively alone.<p>Even people with diabetes live longer on metformin than a control group that is not on metformin. <a href="https://pubmed.ncbi.nlm.nih.gov/25041462/" rel="nofollow">https://pubmed.ncbi.nlm.nih.gov/25041462/</a>
<a href="https://news.ycombinator.com/item?id=31577871" rel="nofollow">https://news.ycombinator.com/item?id=31577871</a><p>This was a recent story that I wish had gained more traction.
It was a great validation, that reversing epigenetics is possible in the human body, but using Yamanaka factors to do the same thing has much more investment dollars behind it (billions vs millions), so I believe it will be ready on the market faster.
If a cheap, reliable technique of halting or slowing down the "epigenetic clock" hits the market, and assuming its main effect on a population level is increased life span, wouldn't it make the demographics of most developed countries even worse?<p>It's still unclear whether or not "automation" will compensate an ageing population, and prevent a demographic collapse. But having a pill that makes people live longer (even if it's 5 to 10 years), wouldn't it be like throwing an entire gas station into the fire?
I saw this article recently that also claimed something called E5 could roll back aging a bit. No idea of the merits of it.<p><a href="https://liveforever.club/blog/harold-katcher-s-e5-elixir-young-plasma-rat-trial-results" rel="nofollow">https://liveforever.club/blog/harold-katcher-s-e5-elixir-you...</a>
So if I am understanding this right, this is turning back the epigenetic clock but not rejuvenating the individual? So it could help prevent aging but not reverse.<p>As we age does our body act differently to make life easier as we get older? If so could this make life worse?