I’m a neuroscientist and have struggled with my (mental) health for 30 years. With the pandemic I realized how much foods affect how I feel every day. Going more than 6 months without eating out I became attuned to the differences of meals I prep and what goes into them.<p>The best explanation I’ve heard is food is like explicit instructions for how our bodies and brains perform through our DNA. Gut health is the engine of the biological machine humming or sputtering accordingly. The research is out there on the differences between food types and impacts of processed foods. The Pollan mantra still still sticks with me: Eat (whole) foods. Not too much. Mostly plants. I’ve added: Sleep better. Move more. Stress less. (To eat well.)
It's interesting that we've become so obsessed with the gut microbiome even though stool only captures a tiny fraction of the composition of the gut.<p>Similarly, the salivary oral microbiome has also been correlated with mental disorders, cognitive health, is modulated by diet, and plays a major role in systemic health. And saliva is objectively easier to collect. Instead of jumping straight into collecting poop, we should be collecting our spit instead!<p><a href="https://www.nature.com/articles/s41398-022-01922-0" rel="nofollow">https://www.nature.com/articles/s41398-022-01922-0</a>
<a href="https://www.nature.com/articles/s41598-021-94498-6" rel="nofollow">https://www.nature.com/articles/s41598-021-94498-6</a>
How does this study relate to fairly recent topic of lack of evidence that low serotonine levels causes depression ? Should the diet metaanalysis be redone after that study ?<p><a href="https://news.ycombinator.com/item?id=32160703" rel="nofollow">https://news.ycombinator.com/item?id=32160703</a>
In the first table the "eating disorders" entry makes references to "Kleinman et al. 2015" and to "Morita et al. 2015". Neither can be found in the bibiography. I couldn't find a paper by some Kleinman on the topic between 2014 and 2016 (<a href="https://scholar.google.com/scholar?start=0&q=author:kleinman+anorexia&hl=fr&as_sdt=7,39&as_ylo=2014&as_yhi=2016" rel="nofollow">https://scholar.google.com/scholar?start=0&q=author:kleinman...</a>). Morita wrote this (<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145274" rel="nofollow">https://journals.plos.org/plosone/article?id=10.1371/journal...</a>).<p>Neither the linked article nor Morita's mention Serguei Fetissov's pioneering work on the topic though, which is disappointing, given that he and his colleagues have long documented the link between <i>E. Coli</i>, the immune system and eating disorders.<p>The gist is that <i>E. Coli</i> produces a protein (CLBP) that mimics a feeding-related hormone (IIRC melanocortin). That protein ends up in the blood stream and can bind the corresponding receptors. It can also generate an immune response, and these antibodies are cross-reactive, causing autoimmunity and complicating the story.
Anyone here drink kefir yogurt? I have kefir grains which I ferment in milk and get a weekly yield of yogurt that I drink out of a bowl after straining the yogurt. It’s packed with probiotics, and helps with my mood. It’s an all round useful elixir to make.
Andrew Wakefield's original disputed paper was about the brain-gut-microbiome axis.<p>Regardless of what you think of Wakefield, and the disservice he (and/or Brian Deer) did with respect to autism and vaccines, an even bigger tragedy to me is that nobody dared to investigate the BGM axis for decades now, for fear of association.<p>It's good to see it back on the list of acceptable research agendas. Perhaps finally the healing can begin.
tldr:<p>> to date there is insufficient evidence from mechanistic human studies to make conclusions about causality between a specific diet and microbially mediated brain function.