> protein pacing diet for the remaining five/six days/week (Protein pacing refers to 4–6 meals/day evenly-spaced, where each meal contains 25–40g of protein)<p>> During fasting days, participants fasting for one day/week were allowed to consume 400 Kcal/day, while participants fasting for two consecutive days were allowed 500 Kcal/day. During non-fasting days the dietary regimen provided 1350 and 1700 kcals/day for women and men, respectively, and a macronutrient distribution consisting of 35% protein, 35% carbohydrate, and 30% fat.<p>That's somehow more calories/day than I would expect for a "fasting day", and fairly restrictive over-all. I'd be curious to hear how these compare to someone on the 1350/1700 kcal/day diet 7 days a week.<p>> Extending beyond 4-weeks reduces compliance and may be overly excessive for a caloric restriction and 2 day IF and create undue metabolic, physiologic, hormonal, and psychological stress in the study participants.<p>Also something I was wondering, the repeated emphasis on short-term benefits has me wonder how the participants did after the trial. Does it do much good if you drop more but it bounces back?<p>> Isagenix International, LLC (Gilbert, AZ, USA) provided all meal replacement shakes, bars, beverages, and supplements.<p>> Whole Blend IsaLean® Shakes, Cleanse for Life®, Ionix® Supreme, Collagen Bone Broth, AMPED™ Hydrate, Harvest/Whey Thins™, IsaDelight® Chocolates,<p>> This study was supported by a grant (IRB#: 1911–859) from Isagenix International, LLC<p>> P.J.A. (the primary author) is a member of the scientific advisory board at Isagenix International LLC, the study’s sponsor. E.G. and A.E.M. are employed by Isagenix International LLC.<p>Ok, that reads as <i>very</i> suspect, now.