I'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile).<p>I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage the doc I worked with in Texas to get my prescription recommended and most people seem to take.<p>Also - I would say that NMN + Rapa is a completely life altering combination for anyone 50+. I feel like I can lift harder and longer now than when I was in my 40's and things seem to be getting easier the farther into my rapa routine I get.<p>Also also - you can find rapamycin online / overseas under its other name - Sirolimus - and the cost is a little lower than getting a proper US prescription.
Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive effects.<p>Anyway, I am tinkering with something in that space - feel free to reach out if you want explore being a co-founder. (email in about)
The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.
This isn't new. David Sinclair wrote about rapamycin in Lifespan[1][2] (I keep linking this book on HN a lot; no relation)<p>[1] <a href="https://en.wikipedia.org/wiki/Lifespan_(book)" rel="nofollow">https://en.wikipedia.org/wiki/Lifespan_(book)</a><p>[2] <a href="https://lifespanbook.com/" rel="nofollow">https://lifespanbook.com/</a>
Please, people. It's bonkers to jump from fruit fly results to humans.<p>Before you take any drug chronically - particularly something KNOWN to block a gene cascade receptor - be sure there are good studies (sufficiently powered, peer-reviewed, phase-III studies in humans with actual endpoints and significant positive results).<p>And be sure the "researchers" you're relying are not just PhD's or retired doctors regurgitating dubious studies.<p>Remember: the essence of a good scam is that it is partly true.<p>Readers will get more longevity from walking instead of reading these studies. Avoiding toenail fungus will improve your lives more. Those have real data behind them.
I have taken this drug several times of the past 10 years. Each time it had a different effect on my immune system and body systems. The first attempt, it really helped with ridding my body of sustained fluid in my lungs. In more recent times it had helped with the same thing. I have a lung disease and it's not a simple thing to treat so they take care to treat it with some new treatments like rapamycin. I am simply stating that I had different and somewhat difficult times while being on the drug. The lung disease that I have is not common and I am immunocompromised, so being on an immunosuppressant drug like this really made me feel ill. I had the influenza A one year while being on it, as well as a couple of cases of pneumonia that put me into a funk. I am glad I was on it, though because it got me to where I need to be. The liquid form tastes disgusting( ya gonna need a chaser) but the pill is not so bad. It did really effect my joints and muscle systems, I was taking from 2 mg down to .5 mg and each time the doses made me feel extremely tired. I am glad that this med is helping people and I hope all that are taking it, are taking this medication seriously. It is no easy task to be on. Drink lots of water.
Best wishes
When somebody asks about what is the next big thing, I always think on anti-aging. If you think that you don’t want to live forever, imagine that today when you arrive home you find a note saying that you will die exactly 1531[^1] days from today. How would you feel?<p>With that said, I would stay away from miracle drugs, because no two human beings have the same physiology. But that’s not an unsolvable problem.<p>[^1]: It’s a random number to “erase hope”. Not knowing when we are going to die keep us slightly hopeful and perky, our mind away from the problem.
I'm 35, have been taking 6mg of rapamycin per week for about a year. It's hard to assign the effects directly to it since I've been taking other supplements and also fixing up my diet + exercise. That being said, I am quite sure that it has reduced general aches and pains, reduced visceral fat and I now have less gray hair compared to when I started. It did slightly increase my glucose and lipids, but still within safe ranges AFAICT. I'll continue to take it until I notice real adverse effects.
There is a super interesting Radiolab episode on the scientist who discovered Rapamycin, and how he himself was taking it to combat colon cancer. It's really good, and the ending has you quite puzzled.<p><a href="https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub" rel="nofollow">https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub</a>
If you sign your dog up for the <i>Dog Aging Project</i>[1], you can get rapamycin for your dog.<p>[1]: <a href="https://dogagingproject.org/" rel="nofollow">https://dogagingproject.org/</a>
FYI one study shows that rapamycin increases amyloid-beta protein plaques in the brains of mice.<p><a href="https://neurosciencenews.com/rapamycin-amyloid-beta-20770/" rel="nofollow">https://neurosciencenews.com/rapamycin-amyloid-beta-20770/</a>
After reading the following article I've tempered my expectations from ramapycin<p><a href="https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/" rel="nofollow">https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-...</a><p>The drug has been known for a long time but human trials always seems elusive
Side effects can be pretty serious, bordering into "probably deadly for a few people" territory.<p><a href="https://en.m.wikipedia.org/wiki/Sirolimus" rel="nofollow">https://en.m.wikipedia.org/wiki/Sirolimus</a>
If it is a reliable alternative to a medicine with similar effects,
I advocate for fasting. I try doing it once per week until 2pm, and once per month till dinner. At some point (years in my case) it became a pleasure.
Some good discussions on rapamycin and longevity on Reddit at <a href="https://www.reddit.com/r/Rapamycin/" rel="nofollow">https://www.reddit.com/r/Rapamycin/</a>
The idea that you could just take a pill one time and be "protected from aging" or something sounds ludicrous. Would be interested to see people reproduce these results and have them supposedly transfer over to humans. Humans are a much longer time scale.<p>I always go back to the SENS concept of having several different problems to solve related to built up damage, cells that won't die, etc.
What's the latest on bloodboys?<p>That is : periodic blood transfusion from healthy young vegan donor.<p>It works very well. Rejuvenates ancient billionaires.<p>Surely it's superpopular among the oligarchs. Probably not the kind of thing you want in the news (vampires!).<p>The technical term is <i>Parabiosis</i>.<p>These guys offer the service : <a href="https://www.ambrosiaplasma.com/" rel="nofollow">https://www.ambrosiaplasma.com/</a>
Dr. Peter Attia did a thorough summary several months ago of what we know about rapamycin as an anti-aging therapy. There are plausible reasons to think it might be safe and effective, but human studies are lacking. This is a promising area for future research.<p><a href="https://peterattiamd.com/ama35/" rel="nofollow">https://peterattiamd.com/ama35/</a>
<a href="https://rapamycinstudy.org/" rel="nofollow">https://rapamycinstudy.org/</a> is collecting data on off-label use according to <a href="https://www.fightaging.org/archives/2022/04/collecting-data-on-people-using-rapamycin-off-label-in-the-context-of-aging/" rel="nofollow">https://www.fightaging.org/archives/2022/04/collecting-data-...</a> (reasonatllm who runs that site hasn't commented on this site recently, perhaps they are busy running <a href="https://www.repairbiotechnologies.com/" rel="nofollow">https://www.repairbiotechnologies.com/</a>)
Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections?<p>David Sinclair got me interested in this topic.<p>Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.
Tangentially related - it seems there are other things that, if experienced early enough in life, have significant health benefits that are triggered if-and-only-if the catalyst occurs at the right time. For example, pregnancy at a young age is associated with a significant decrease in breast cancer risk. My recollection is this benefit of pregnancy disappears once a women is in her late teens. Our bodies are wildly interesting.<p><a href="https://pubmed.ncbi.nlm.nih.gov/24355762/" rel="nofollow">https://pubmed.ncbi.nlm.nih.gov/24355762/</a>
I have been taking rapamycin for many years now. It's obviously not ready for anywhere near the general public and is never something I'd suggest to someone at this point, but my own results have been wonderful and my blood panels and energy levels are great. If I had to guess, when properly used, this would probably add a full 5-10 years onto the lifespan of a lot of people. When combined with many other promising treatments, I think we could easily add 10-15 years onto most peoples' health+lifespans.
There seems to be a growing trend of generally healthy people looking for drugs/supplements to provide marginal improvements. I can't help thinking it's a sign of a vacuous and unfulfilling life. Instead of spending time and money on drugs to increase your life span, why not spend that time/money on actually living your life? I think this probably comes down to the general boredom that comes from not having a family and not having enough time off work to do anything else worthwhile.
Maybe I missed this, but 2 weeks in fruit flies and 3 months in mice probably translates into something much longer in humans, on the order of a year or two maybe, if not longer? That's a pretty long time to be on an immune-suppressing drug with pretty significant side effects.<p>It's still an important bit of information if it replicates, but I think it might not be as clinically practical as it sounds from the press release.
There was an in depth discussion about this drug with a longevity researcher on a recent episode of the Tim Ferriss podcast, in case anyone wants to dive deeper.
There are other natural mTOR inhibitors:<p>- EGCG (found in green tea)<p>- Vitamin D3<p>- Curcumin<p>- Resveratrol<p>- Genistein, an isoflavone found in soybeans<p>- 3,3-Diindolylmethane (DIM), found in cruciferous vegetables<p>- Caffeine
the gist of it<p>"""
The scientists have tested different time windows of short-term drug administration in fruit flies and found that a brief window of 2 weeks of rapamycin treatment in young, adult flies protected them against age-related pathology in the intestine and extended their lives. A corresponding short time window, 3 months of treatment starting at 3 months of age in young, adult mice, had similar beneficial effects on the health of the intestine when they were middle-aged.<p>“These brief drug treatments in early adulthood produced just as strong protection as continuous treatment started at the same time. We also found that the rapamycin treatment had the strongest and best effects when given in early life as compared to middle age. When the flies were treated with rapamycin in late life, on the other hand, it had no effects at all. So, the rapamycin memory is activated primarily in early adulthood”, explains Dr. Thomas Leech, co-author of the paper.
"""<p>And here I am wondering what the cutoff is for middle age...
genuine question: why would someone want to live longer than the average?<p>Edit:
I ask because I personally don't see a reason to stay alive while people I love are dying, I don't see a reason to stay alive in an already fucked up planet, while we empty all the resources, etc. But you guys are so smart, intelligent and clever, why even bother.