"Farrar: When the sequence of SARS-CoV-2 was released on January 10, 2020, some features stood out that at first glance looked unusual and therefore suspicious. However, as I see it today, this was mainly due to our level of knowledge at that time. It then became apparent quite quickly that the characteristics that initially looked alarming were also found in other natural coronaviruses. Moreover, in retrospect, we see that the wild type of the virus in Wuhan was by no means optimally adapted to humans; Omicron is much better adapted. Apart from the location of the outbreak, Wuhan, there is actually nothing that speaks for a lab leak. For me, the probability that SARS-CoV-2 originated in animals is over 90 percent."