TE
TechEcho
Home24h TopNewestBestAskShowJobs
GitHubTwitter
Home

TechEcho

A tech news platform built with Next.js, providing global tech news and discussions.

GitHubTwitter

Home

HomeNewestBestAskShowJobs

Resources

HackerNews APIOriginal HackerNewsNext.js

© 2025 TechEcho. All rights reserved.

Alzheimer's drug lecanemab hailed as momentous breakthrough; targets root cause

12 pointsby cwwcover 2 years ago

4 comments

kalimanzaroover 2 years ago
Not in the BBC article:<p>&quot;Second death linked to potential antibody treatment for Alzheimer’s disease<p>Woman’s brain hemorrhage while receiving Eisai’s widely heralded lecanemab heightens concerns overs its safety 27 NOV 2022•8:00 PM•Science<p>&quot;Rudolph Castellani, a Northwestern neuropathologist who studies Alzheimer’s and conducted an autopsy at the request of the patient’s husband, called the case “very dramatic.” The report, co-authored by Castellani, concluded that the woman, like the other person whose death was linked to lecanemab..&quot;,<p><a href="https:&#x2F;&#x2F;archive.ph&#x2F;FkYss" rel="nofollow">https:&#x2F;&#x2F;archive.ph&#x2F;FkYss</a><p><a href="https:&#x2F;&#x2F;archive.ph&#x2F;nye78" rel="nofollow">https:&#x2F;&#x2F;archive.ph&#x2F;nye78</a>
dkuralover 2 years ago
It&#x27;s far from clear that this is the &quot;root cause&quot;. There is a good chance any therapeutic effect goes away after larger trials, like every single other drug targeting the same mechanism so far.
elischleiferover 2 years ago
This disease is just absolutely devastating; I remember reading over the past couple years how the connection between protein buildup and alzheimers was being questioned more in the research. When a momentous breakthrough is a 25% delay in symptoms - you know things are bad.
klooneyover 2 years ago
And no mention of the fight over the amyloid hypothesis