Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug.<p>The headline is editorialized. The linked article's headline: The ‘next Ozempic’ became a social media sensation. Then everything changed<p>The coupon didn't go away. The coupon's terms changed. I'm using the coupon now. Because I have type 2 diabetes. The coupon changed because people were using it to get the drug for off-label use. The drug wasn't taken away from people trying to lose weight by jacking up the cost. The drug shouldn't have been dispensed in this way to begin with.<p>Lilly is seeking to get approval of tirzepatide under a different label as a weight loss drug, similar to how Ozempic and Wegovy exist, as well as Victoza and Saxenda.<p>If you want a GLP-1 RA (this drug class) for weight loss, go get Wegovy or Saxenda, which are a version of these drugs approved for weight loss for those with a BMI over 30, or wait for the tirzepatide version. Leave the diabetes drugs alone.<p>And to be clear: This drug isn't helping diabetics by helping them lose weight. It helps diabetics regulate blood glucose. It slows the release of glucose from the liver as well as promotes the release of insulin from the pancreas. Weight loss due to slowed stomach emptying is a side effect.
<a href="https://astralcodexten.substack.com/p/semaglutidonomics" rel="nofollow">https://astralcodexten.substack.com/p/semaglutidonomics</a><p>These new weight loss medications are the solution to obesity. Imo this is one of the biggest medical advances of the century and at least in urban areas of wealthy countries, I don’t think we’ll see obese people anymore in 10 years.<p>The pharma companies realized they’ve got something truly revolutionary so they took the old tried and true drug dealer strategy. Get ‘em hooked for free/cheap and then bump the price to capture the value. Can’t say it’s surprising, they’re just following the incentives. And as the link goes through, these drugs have the potential to be worth many billions of dollars over their lifespan.
> When someone takes an anti-obesity medication like Mounjaro, the amount of fat the body wants to maintain is re-regulated, usually to a lower weight. “When you take the medication away, that defended fat mass goes back up, and weight is regained,” Jastreboff said. “In order to continue to maintain the new re-regulated defended fat mass, and weight reduction, you have to continue taking the medication.”<p>This doesn’t seem worth it to me. I’m sure a lot of people would like to lose 25lbs but you’re making a deal with the devil to get it. It almost makes me think they design these drugs to make a recurring revenue stream instead of fixing the issue permanently.
Tragic to observe the typical Dallas Buyers Club dynamic at play. People are coordinating online and locally and doing border runs for the Mexico-available GLP-1 predecessors.<p>The Mounjaro patent appears to be until '39, with no generics available at the moment.<p>As one of the patients states in the article, obesity may very well lead them to diabetes. People will die. And with the shortage affecting current diabetics, they are dying now.
The obese are mad at the diabetics, the diabetics are mad at the obese, while they should be mad at their failure of politicians who won’t regulate the drug market like any other functioning democracy. It’d be funny if it wasn’t so tragic
If you haven't heard about Mounjaro before this Wired article by Paul Ford is worth your time: <a href="https://www.wired.com/story/new-drug-switched-off-appetite-mounjaro/" rel="nofollow">https://www.wired.com/story/new-drug-switched-off-appetite-m...</a>
I understand that $25 may have been an introductory loss leader but $1k seems insane and short sighted given the size of the market this drug potentially has.
What we really need is more fighting and hating and blaming and corporate greed and general incivility.<p>That’s sure to make everything better for everyone.
One of the flaws of our culture is that we madly overrate convenience. We think everything should be as easy as possible. It is taken as self evident but if you spend some thought on it it is hard to escape how important effort and accomplishment are. If we learn how to push ourselves we can take on slightly larger goals every time. Don't take my words as some kind of expert on the topic, if anything it reminds me constantly how damn lazy I am and how much worse it got. What kind of challenge you take up or find yourself in doesn't matter, it is all the same discipline. If I'm not careful the significant other will do all the house chores, cook the food and pay for everything. Imagine how appealing that sounds! This comment could have been a very lengthy article full of good references, the kind I haven't written in a long time. For this audience it could have used programming as it's context. What if after learning to read and write we would all learn to use a cli? Anyone could learn basic SQL and if we ever get the tools sorted out we could all consume API's. Very little effort and a huge reward. In stead some of us have to fight the html forms so that a baby can make very limited use of it. Lets have them type their name and their email and their address by hand? What horrific waste of time?<p>We already force people to go to school and in some countries you have to join the military but after that we are free to never exercise again and stuff our face with any kind of food we want the year round. If we are financially successful we will never have to use our brain. Can get drunk and stoned every day.... wonderful? You can smoke, drink coffee and watch tiktok indefinetly... at least until any kind of challenge presents it self. Then ur fucked. Not very funny in a personal context but as a society or a culture things should get rather bizarre as we pile up more and more convenience. We already have to import people to do the work.<p>It seems cheap universal healthcare isn't as hard as it seems. Putting out a small fire and cleaning up is cheaper than letting the entire city burn down before doing anything.
The company that gouges customers for life saving insulin (edit: not epipens) gouges customers for another life saving drug.<p>Capitalism, ho!<p>(If you accept that obesity kills, reducing obesity saves everyone’s money and lives)
The story itself doesn't mention TikTok at all, it's really strange that the headline makes it the key aspect of the article.<p><i>edit</i> now the title here has changed, but it's still strange The Independent list that as the most important part. Guess it's normal click bait tactics.
Cynically speaking, main reason people lose weight, is looks and advantage in dating it gives (unless they are morbidly obese and at risk of severe illness or death due to that, of course).
If there was a $25 a month drug that lets everyone become skinny, then what's the point? Advantage will cease to exist.