<i>The TK6 cells were exposed to 20 concentrations of sucralose-6-acetate (maximum 4.5489 mM or 2000 μg/ml) or 20 concentrations of sucralose (maximum 10 mM or 3980 μg/ml)</i><p>If you look at the genotoxic Multiflow results (tables 3-4), the genotoxic signals only showed up at the highest concentrations (>300 ug/mL).<p>Peak concentrations of sucralose in blood after consumption is ~300 ng/mL, so about 1000x fold less.<p>Also note the paper showed <i>non-mutagenicity</i> in the bacterial reserve mutation test (Ames Test).<p>So the results are interesting, but I'm not sure how applicable they are to actual exposure in humans.
Every time one if these stories pops up, I feel compelled to point out that artificial sweeteners have been tied to weight gain, so unless you are diabetic, there’s no reason to ingest them.<p>In general, they cause your metabolism to slow down, and make you feel hungrier. Giving them to mice on calorie restricted diets causes weight gain and lethargy in the mice.<p>Giving a subjectively identical amount of sugar to the mice (on top of the calorie restricted diet) causes less weight gain than the artificial sweeteners. (Because the mice stay active.)
Interesting that this refers to "Enhanced intestinal permeability (leaky gut)", which wikipedia insists is very different than "leaky gut syndrome" which it describes as "a hypothetical, medically unrecognized condition"
Is this a legitimate site or one of those sites that e.g. showed NOAA ocean waves height data after the Fukushima tsunami and claims it shows radiation levels across the Pacific?<p>You know the type, generic domain name that sounds vaguely news-related, cheap-looking logo, suspicious by-lines...<p>Edit: well the content is legit, but since it's stolen from [1], that proves this "SciTechDaily" is a content farm..<p>[1] <a href="https://bme.unc.edu/2023/06/chemical-found-in-common-sweetener-damages-dna/" rel="nofollow">https://bme.unc.edu/2023/06/chemical-found-in-common-sweeten...</a> - an .edu URL is more trustworthy...
I still can’t believe that sucralose ever passed a safety trial. When has it ever been sensible to eat chlorocarbons? It’s amazing that it took this long to find some kind of genotoxic effect.