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Whole-brain connectome of the fruit fly

190 pointsby jacobedawsonalmost 2 years ago

12 comments

lhlalmost 2 years ago
Related:<p>* Fruit Fly Brain Observatory <a href="https:&#x2F;&#x2F;www.fruitflybrain.org&#x2F;#&#x2F;posts&#x2F;explore_ffbo" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.fruitflybrain.org&#x2F;#&#x2F;posts&#x2F;explore_ffbo</a> which lets you visualize and explore datasets<p>* Neurokernel <a href="http:&#x2F;&#x2F;neurokernel.github.io&#x2F;" rel="nofollow noreferrer">http:&#x2F;&#x2F;neurokernel.github.io&#x2F;</a> - open source software which &quot;aims to build an open software platform for the emulation of the entire brain of the fruit fly Drosophila melanogaster on multiple Graphics Processing Units (GPUs).&quot; See also: <a href="http:&#x2F;&#x2F;www.bionet.ee.columbia.edu&#x2F;projects&#x2F;neurokernel" rel="nofollow noreferrer">http:&#x2F;&#x2F;www.bionet.ee.columbia.edu&#x2F;projects&#x2F;neurokernel</a><p>The recent work being published on this is pretty wild:<p>* <a href="https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC7614541&#x2F;" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC7614541&#x2F;</a> (summaries: <a href="https:&#x2F;&#x2F;www.spectrumnews.org&#x2F;news&#x2F;wiring-map-reveals-how-larval-fruit-fly-brain-converts-sensory-signals-to-movement&#x2F;" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.spectrumnews.org&#x2F;news&#x2F;wiring-map-reveals-how-lar...</a> and <a href="https:&#x2F;&#x2F;www.nih.gov&#x2F;news-events&#x2F;nih-research-matters&#x2F;complete-wiring-map-insect-brain" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.nih.gov&#x2F;news-events&#x2F;nih-research-matters&#x2F;complet...</a>)<p>Oh, and just in case people haven&#x27;t read this, I&#x27;ll just drop this short story from a few years ago Lena (MMacevedo): <a href="https:&#x2F;&#x2F;qntm.org&#x2F;mmacevedo" rel="nofollow noreferrer">https:&#x2F;&#x2F;qntm.org&#x2F;mmacevedo</a> - like with AI, I think science fact will be rapidly catching up w&#x2F; fiction soon.
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soderfooalmost 2 years ago
Visual processing requires an astounding amount of brain power. Over 50% of a fruit flies brain cells are dedicated to their rudimentary visual system.<p>Comparatively, the human visual processing system is truly astonishing and I am grateful for it.
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apialmost 2 years ago
Can I pair this with adversarial deep learning to develop a way to trap these in my kitchen? I live in the Midwest and they are like a plague of locusts but tiny and annoying and strangely aware of countermeasures.<p>Or maybe I can apply fruit fly Roko’s Basilisk and threaten to simulate fruit fly brains in agony if the flies don’t leave me alone on the theory that since I am able to simulate a fruit fly brain I am fly basilisk?
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FrustratedMonkyalmost 2 years ago
Didn&#x27;t quite catch, is this just the first mapping, or are they able to &#x27;execute it&#x27;. Like the worm project a few years ago. Where they mapped worm &quot;C. elegans&quot; brain, and was able to put in a simulated environment and watch reactions, and eventually into a robot body.<p>This seems like next step up in complexity, so wondering how far they are along having the &#x27;brain map&#x27; execute.
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chaxoralmost 2 years ago
Awesome! Are there any simple downloads that have just annotations and connectivity? Like a sparse adjacency matrix with annotations of the node and edge features (neuron type, etc). I didn&#x27;t see any immediately. A condensed representation of the 3d model should be pretty great for researchers as well.
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foreign_legionalmost 2 years ago
I think logical and incremental next step is the whole brain connectome of business analysts at bank of america technology division.
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rbanffyalmost 2 years ago
Would instantiating this network and feeding it random inputs be akin to animal cruelty?<p>Would you run tests on a cat connectome? A human’s? Yours?
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ourafalmost 2 years ago
Ooh, i think i remember this one: It had the cosmic coincidence of one of its researchers being called Timothy MOSCA.<p><a href="https:&#x2F;&#x2F;www.smithsonianmag.com&#x2F;smart-news&#x2F;see-the-first-complete-map-of-an-insects-brain-180981778&#x2F;" rel="nofollow noreferrer">https:&#x2F;&#x2F;www.smithsonianmag.com&#x2F;smart-news&#x2F;see-the-first-comp...</a><p>good to see it got some more attention.
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jacobedawsonalmost 2 years ago
Codex provides access to proofread static snapshots of the FlyWire full-brain connectome - wiring diagram of Drosophila brain.
ranting-mothalmost 2 years ago
This is very interesting. Any wild guesses how far (in years) away from building a synthetic fruit fly? 10 years?<p>By synthetic I mean a fly that doesn&#x27;t die and that can be reproduced again.
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causality0almost 2 years ago
Is this an actual whole-brain connectome or is it that same work based on a larval brain with several orders of magnitude less complexity than an adult fly brain?
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autophagianalmost 2 years ago
There&#x27;s lots of very exciting work going on around the fully mapped fruit fly connectome. For example, I&#x27;m a CTO of a stealth startup that aims to do for utilitarianism what carbon credits did for environmentalism. We are selling &#x27;utility credits&#x27; which translates directly into us simulating trillions and trillions of fruit fly brains in a state of constant orgasmic bliss, which you can then buy to offset any actions your company has undertaken that damage global happiness or well-being. We&#x27;ve seen a lot of interest from some pretty large industry players.
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