Many people go to work at jobs that aren’t designed to be fulfilling, and many more don’t get the chance to contribute at all. Meanwhile, many powerful organizations are forced to focus on their own profitability and short-term goals at the expense of everything else — leaving the status quo intact, or at best only making the world incrementally better. Yet the massive problems facing us this century need the widest array of minds, the wildest imaginations, and enormous commitments of time, resources, and attention.