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Every genetic mutation that could exist, does exist

18 pointsby Michelangelo11about 1 year ago

6 comments

exmadscientistabout 1 year ago
<i>Single-point</i> mutation. I know the author thinks that leaving out that qualifier makes the claim sound cooler, but it doesn&#x27;t. It makes the claim sound wrong. Because the unqualified claim <i>is</i> wrong. There are a lot more things in this world than single-point mutations.
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skywhopperabout 1 year ago
Clarifying the headline: Every mutation of a single nucleotide of the human genome that could exist likely does in the human population. Just statistically this is very likely if not certain.<p>His second line of “but all the beneficial ones haven’t had time to become ubiquitous” reveals a weird misunderstanding of how evolution works. Not all beneficial mutations would necessarily ever become “ubiquitous”. And few if any mutations, especially on the scale of a single nucleotide, could fairly be characterized as objectively and universally “beneficial”. Environment and context is crucial.<p>Take the example of sickle cell disease, which can be caused by a single nucleotide mutation. It can cause many problems in its sufferers but it can also confer its carrier with resistance to malaria. Whether its a beneficial mutation depends entirely on the environment, from prevalence of malaria to availability of treatment for the various symptoms.
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r34about 1 year ago
I don&#x27;t understand something: I was taught that mutations are random, not even predictable (the latter comes from Stuart A. Kauffman book that I&#x27;ve read recently). How did they construct the set of &quot;all possible mutations&quot;? Do we even know enough on chemistry &#x2F; physics level to make such claims?
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scotty79about 1 year ago
I think there&#x27;s zero humans that have single point mutation that&#x27;s immediately lethal.<p>But it should hold true for nonharmful potentially beneficial single point mutations.<p>So I guess X-Men is not entirely accurate unless they are fueled by more complex mutations.
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FrustratedMonkyabout 1 year ago
1. Is this because natural selection isn&#x27;t driving them out anymore, because modern medicine lets them live long enough to re-produce.?<p>2. Is this how you get the X-Men?
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PUSH_AXabout 1 year ago
Would someone be kind enough to ELI5?
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