It's fascinating to me that a pure element would have such immediate and significant effects on the human mind. I would think that this would generally require a more complex molecular shape that can fit with various receptors in the body and trigger the release of dopamine and other neurotransmitters.<p>Apparently, Xenon does this by acting as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor, and also by enhancing the effect of ("potentiation of") gamma-aminobutyric acid (GABA). Other drugs that act along the NMDA pathway are Ketamine and Memantine (an Alzheimer's drug). And other drugs that act along the GABA pathway are Benzodiazepines (e.g., Diazepam, Lorazepam-- i.e,. Valium). And apparently Nitrous Oxide (N2O) uses both mechanisms as well.
In college I used a lot of nitrous. I got small cartridges and a “cracker” with a balloon. It was pretty euphoric.<p>I stopped after recording myself taking it. I was unconscious a lot longer than I remembered being, and even though I was probably never at risk of suffocating there were long periods where I didn’t see myself breathing. That was enough.<p>I regret the effects it may have had on my brain. It’s impossible to know the counterfactual “what if” and maybe binge drinking was worse.
There is another post that is sounding an alarm on inert gas asphyxiation which I think is quite important but it's flagged, presumably because of a sidebar admonishment about drug addiction.<p>Breathing inert gasses is extremely dangerous. It is not like holding your breath: because the gas you inhale is free of oxygen, it actively pulls oxygen out of your blood. Instead of thinking about breath holding, think more like the USCSB videos where someone walks into a space with a nitrogen atmosphere and immediately drop unconscious, then someone goes in to save the first person (already knowing about the danger) and they both die. ( <a href="https://www.youtube.com/watch?v=f2ItJe2Incs" rel="nofollow">https://www.youtube.com/watch?v=f2ItJe2Incs</a> ).<p>When narcotic gasses are used for anesthetic purposes they're used with a gas manifold that mixes in pure oxygen to achieve a gas mix that won't kill the subject. Even this is easy to get wrong, and a wrong mix due to a flat tank or an incorrect setting can kill someone very quickly and quietly.<p>It's also not clear to me how psychologically safe it is, I've seen at least one clearly unhinged person on twitter going on about their xenon use... but I dunno if the drug use lead to they psych issues or the psych issues lead the the drug use. or if their issue was just related to inadvertent oxygen deprivation as a side effect of their xenon use. Studies of anesthetic use may not tell us much about recreational use since they're presumably not dosing people daily or multiple times daily for weeks at a time. -- it's not like you can easily purchase single doses, that bottle isn't going to use itself!
Cody of the Cody's Lab youtube channel has a video of what his voice sounds like after breathing each of the noble gasses. He certainly seemed to be experiencing symptoms afterward!<p><a href="https://www.youtube.com/watch?v=rd5j8mG24H4&t=418s" rel="nofollow">https://www.youtube.com/watch?v=rd5j8mG24H4&t=418s</a>
It's a shame xenon is an anesthetic. If it did not have that effect, one could pressure xenon until it was the same density as the body. It would still be a gas, and one could include some oxygen in it so one wouldn't suffocate (although breathing could be more laborious, perhaps require mechanical support).<p>Suspended in this gas, one could be subjected to much higher acceleration without injury, up the point that density differences in the body become important.
Xenon is also produced as a fission product in nuclear reactors. In fact, if you're not careful it will accumulate and inhibit your nuclear reaction. In German, the term for this is xenon-poisoning.
<a href="https://www.erowid.org/experiences/subs/exp_Xenon.shtml" rel="nofollow">https://www.erowid.org/experiences/subs/exp_Xenon.shtml</a><p>Erowid has some other records of it. Sounds like nitrous but probably better. I wonder if humans evolved to react this way to certain gases or if its a coincidence.
Haha I remember an old trip report about this on Erowid.<p>There's a few of them on there <a href="https://www.erowid.org/experiences/subs/exp_Xenon.shtml" rel="nofollow">https://www.erowid.org/experiences/subs/exp_Xenon.shtml</a>
> Argon [...] cost about $2 per liter each.<p>Uh, what?? No it doesn't.<p>I'm a hobbyist welder. When TIG welding you typically use 100% argon gas. I have a 60 cu ft cylinder hooked up to my welder right now; it costs $89 to refill at my local Airgas store.<p>That's approximately 5.2 cents per liter.<p>Here's a 40 cu ft tank of argon for sale on Amazon for $205: <a href="https://www.amazon.com/100-Argon-Welding-Tank-CGA/dp/B00I4Z69S0/" rel="nofollow">https://www.amazon.com/100-Argon-Welding-Tank-CGA/dp/B00I4Z6...</a><p>That's a new cylinder so most of the cost is the cylinder itself, but even then, that only comes out to 18.1 cents.<p>How on earth did TFA come up with $2/liter? Did they get liters and cubic feet mixed up while doing their research?
dissociative effects so powerful you'll never perceive the world the same again doesn't sound like a great selling point in the worlds best anaesthetic
I find a lot of these casual drug use articles to be a bit naive on safety. “It does not cause metabolites or react” well it obviously modifies several biochemical processes in order to have an effect, who knows what long term effects it has on your brains computation. Our understanding of the biochemical interactions of various systems is still exceedingly immature. It’s best to say that from a safety perspective it probably won’t kill you straight away… and it might not screw up your personality straight away.
The Xenon episode of Hamilton's Pharmacopeia is one of the very best episodes of that series, I don't know the best way to find it on streaming currently, it was available I believe on Netflix (or maybe it was Hulu?): <a href="https://www.vicetv.com/en_us/video/xenon-the-perfect-anesthetic/5fd3b93bd4b2c85e6438b4cb" rel="nofollow">https://www.vicetv.com/en_us/video/xenon-the-perfect-anesthe...</a><p>The full episode takes very disturbing twists and turns, worth a watch.
I've done Xenon a fair number of times, it is definitely the Rolls Royce of inhalants. I'd recommend it to anyone as long as you can divert a little and aren't paying for it yourself. If you don't have unlimited amounts of money, it simply is not worth it.<p>If you're looking for a great NMDA inhalant experience I'd recommend another classic 19th century anesthetic, diethyl ether. It is extremely simple to produce -- heat everclear and sulfuric acid together and distill. Adjust the PH afterwards. Anyone can make diethyl ether. The actual meat of the ether experience is actually on par with Xenon. I'd say the only element that makes it worse is the aftertaste.<p>It's still a tradition among Lemkos in the Carpathians (Slava Ukraini!) to drink ether. Drinking is a little trickier, as the boiling point of ether is lower than your body temperature. You should chew and swallow some crushed ice beforehand, and also serve a bit in a shotglass with some crushed ice and lemon shaved ice to offset the taste. I've also found pina colada mix to be a great accompaniment. If you're just starting out with ether I recommend just inhaling the vapor.
> Xenon is unique among psychedelic drugs because it’s a pure element. It leaves the body exactly as it entered, completely unchanged.<p>I very doubt it is true. The article poorly hand waves later that a brain without oxygen will starve.<p>I bet shooting this crap for some short term high will burn your brain cells, even if mixed with oxygen.
These days we have some theory about this. See Stuart Hameroff MD, a Professor of Anesthesiology and Psychology, and Director of the Center for Consciousness Studies at the University of Arizona.<p>To sum it up from my limited understanding: This disturbs the quantum coherance in the microtubelies in all cells (But mostly nurons) which is needed for consciousness to "limit" itself to a identity.