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bbor10 months ago
The paper: <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41586-024-07701-9" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41586-024-07701-9</a><p>My amateur understanding: they’re pretty blindly inhibiting a hormone that causes inflammation, and is released (partially) in response to cellular senescence (&#x2F;deterioration). And it looks like it was successful!<p>Can an expert explain why such a thing is promising? Maybe it’s not, but they don’t mention it until the Results? Just to my layman brain, it seems likely that inflammation in response to senescence might, like, have a function in the first place…<p>I guess that’s what empiricism is! Pull some levers that seem like they shouldn’t be pulled, and write down when one of them works better than expected!
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kristianp10 months ago
92 points | 88 comments:<p><a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=40987224">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=40987224</a>