I read a cool study, apparently there’s a condition called “congenital insensitivity to pain”<p>There’s some gene, that if it doesn’t work right, you can’t feel pain. I think it does what this drug targets, regulate sodium flow.<p>Apparently they did CRISPR on some rats and disabled the gene, preventing sodium flow through the protein, and it worked to suppress pain. Interestingly it also suppressed the ability to smell! I can’t find the source right now.<p>I do remember, however the article I read said that they had been trying to find drugs that could do the same, but it was really tricky to find the right protein to block the transmission of chemicals.<p>Looks like they are finally making progress!
Wikipedia entry:<p><a href="https://en.wikipedia.org/wiki/Suzetrigine" rel="nofollow">https://en.wikipedia.org/wiki/Suzetrigine</a>
Be careful what you wish for.<p>Wikipedia entry:
<a href="https://en.wikipedia.org/wiki/Congenital_insensitivity_to_pain" rel="nofollow">https://en.wikipedia.org/wiki/Congenital_insensitivity_to_pa...</a>