Simulating 500M years of evolution with a language model

preprint, <a href="https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2024.07.01.600583v2" rel="nofollow">https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.1101&#x2F;2024.07.01.600583v2</a><p>previous discussion, <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=40787800">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=40787800</a>

The proteins that exist today have developed into their present forms over the course of billions of years of natural evolution, passing through a vast evolutionary sieve.