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Scientists crack how aspirin might stop cancers from spreading

171 pointsby SirLJ3 months ago

11 comments

Modified30193 months ago
&gt;Part of our immune defences - a white blood cell called a T-cell - can swoop in and destroy the spreading cancer as it tries to take root.<p>&gt;But the study showed that another part of our blood - the platelets that normally stop bleeding - were suppressing the T-cells and making it harder for them to take out the cancer.<p>&gt;Aspirin disrupts the platelets and removes their influence over the T-cells so they can hunt out the cancer.
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NewUser763123 months ago
There&#x27;s a niche online health community which follows the work of a late Dr. Ray Peat, who have been touting the benefits of aspirin for a long time:<p><a href="https:&#x2F;&#x2F;raypeat.com&#x2F;articles&#x2F;aging&#x2F;aspirin-brain-cancer.shtml" rel="nofollow">https:&#x2F;&#x2F;raypeat.com&#x2F;articles&#x2F;aging&#x2F;aspirin-brain-cancer.shtm...</a><p>Some of Dr. Peat&#x27;s disciples have even begun their own independent cancer research (in mice) trying to prove efficacy of far more basic interventions:<p><a href="https:&#x2F;&#x2F;x.com&#x2F;haidut&#x2F;status&#x2F;1751716166387597730" rel="nofollow">https:&#x2F;&#x2F;x.com&#x2F;haidut&#x2F;status&#x2F;1751716166387597730</a><p>I&#x27;ve been an observer of this sphere since ~2017, have implemented various Peat-related concepts towards my own health and fitness, to overall positive results. What&#x27;s interesting is seeing more and more of these theories - under the theme of &#x27;bioenergetics&#x27; - starting to be proven out even in conventional research.
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bell-cot3 months ago
&gt; The team at the University of Cambridge said it was an exciting and surprise discovery that could eventually lead to cancer patients being prescribed the drug - but not yet and people are advised against just taking the pills themselves.<p>While the Ethics Panel and solicitors may have ordered the researchers to say that, I&#x27;m thinking that anyone with serious cancer should (1) start taking aspirin, (2) read a bit about aspirin side-effects and contra-indications, then (3) let their doctor know that they did (1) and (2).
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sema4hacker3 months ago
I had a heart bypass 29 years ago and my daily meds since then included a baby aspirin, but a year or so ago the occasional rectal bleeding got really bad. Stopped the aspirin and the bleeding went away.
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achillesheels3 months ago
So is here any positive correlation with cancer survivor rates with those with low to extremely low platelets? Excluding blood cancers of course .
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gnabgib3 months ago
Paper: <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41586-025-08626-7" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41586-025-08626-7</a> (<a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=43270665">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=43270665</a>)
veunes3 months ago
What works in mice doesn&#x27;t always translate to humans, and aspirin&#x27;s risks (like internal bleeding) mean it&#x27;s not a simple &quot;just take it&quot; solution... Yet still it could be a game-changer for early-stage cancer treatment
m0llusk3 months ago
Oddly critical that this research is going on in London. If this were in the US then current efforts to shut down the National Institute of Health would have everything about present and future in a muddle.
nikolay3 months ago
Enteric-coated aspirin is safer, but it does nothing. It is best to take plain aspirin with vitamin C and&#x2F;or DGL - studies show both protect the lining of the stomach from ulcers. That&#x27;s why Aspirin C in Europe is the best combo! Haidut, one of the most prominent Ray Peat&#x27;s followers and translators, if I could characterize him like this, told me that he just combines aspirin with collagen, and it does the same thing.
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luizfzs3 months ago
I hate these types of headlines that omit an important part of the context: The study was conducted in mice. We&#x27;re not mice.<p>The results are encouraging but in no way conclusive for humans. They open for the opportunity for broader studies, studies in humans. That&#x27;s all they do.
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sharpshadow3 months ago
I don’t understand why they are still referring to acetylsalicylic acid (ASA) as Aspirin. Aspirin today can be a mixture of ingredients but what the described effects are about is ASA.
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