Maybe I am completely off track, but you don't need radioactive marker molecules if you go for two-photon imaging, you need fluorescent markers.<p>Also, it is sad to see that even today, every publication in the neurobiology field has to mention Alzheimer's. It's about finding how the brain works, and if it is applicable to Alzheimer's, then great, but at the current state, this is a very long shot.
Could this be why vasodilators like vimpocetine improve mental performance? Maybe it's half about getting more nutrients to the brain and half improving the garbage collector?
To me, this article boiled down to two sentences: "Cerebrospinal fluid flowed along the outside of blood vessels, carried through a network of pipe-like protein structures. The fluid picked up waste that accumulated between cells, then drained out through major veins."<p>Unfortunately, it didn't deal with intracellular waste, which is a major issue over a lifetime. The only known
way of addressing that is through caloric restriction. Some links:<p><a href="http://www.hyperink.com/Fasting-For-Cleansing-Autophagy-b274a336" rel="nofollow">http://www.hyperink.com/Fasting-For-Cleansing-Autophagy-b274...</a><p><a href="http://www.pittsburghpatrika.com/2012/06/fasting-is-good-for-you-it-helps-remove-waste-debris-at-the-cellular-level/" rel="nofollow">http://www.pittsburghpatrika.com/2012/06/fasting-is-good-for...</a><p><a href="http://www.nature.com/cdd/journal/v12/n2s/fig_tab/4401728ft.html" rel="nofollow">http://www.nature.com/cdd/journal/v12/n2s/fig_tab/4401728ft....</a><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670399/" rel="nofollow">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670399/</a><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/16874025" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/16874025</a><p><a href="http://www.sciencedirect.com/science/article/pii/S0969996109000047" rel="nofollow">http://www.sciencedirect.com/science/article/pii/S0969996109...</a><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670399/" rel="nofollow">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670399/</a><p>Bottom line, there is NO FREE LUNCH!