Substantial improvements in the environmental sustainability of agriculture are achievable now, without sacrificing food production or farmer livelihoods. When agrichemical inputs are completely eliminated, yield gaps may exist between conventional and alternative systems. However, such yield gaps may be overcome through the strategic application of very low inputs of agrichemicals in the context of more diverse cropping systems. Although maize is grown less frequently in the 3-yr and 4-yr rotations than in the 2-yr rotation, this will not compromise the ability of such systems to contribute to the global food supply, given the relatively low contribution of maize and soybean production to direct human consumption and the ability of livestock to consume small grains and forages. Through a balanced portfolio approach to agricultural sustainability, cropping system performance can be optimized in multiple dimensions, including food and biomass production, profit, energy use, pest management, and environmental impacts.