Alfred can global hotkey system commands. You could try binding that key to `open /Applications/Spotify.app` or something similar.<p><a href="http://support.alfredapp.com/tutorials:global-hotkeys" rel="nofollow">http://support.alfredapp.com/tutorials:global-hotkeys</a><p>This probably isn't the best forum for a question like this though, try <a href="http://superuser.com/" rel="nofollow">http://superuser.com/</a> if Alfred doesn't work for you.