Read Asimov. It's all there. It comes down to space travel.<p>Presumably, the ultimate propulsion will be nuclear-boiled water ejected out of a nozzle as steam. I suppose you could do something similar with other low molecular weight (stable bonds), low atomic weight (plentiful in post-stellar debris) fluids, but water's on a sweet spot in terms of caloric density. Hydrocarbons would probably be good, so I suppose you could mine the atmospheres of the gas giants for those. Interstellar travel will involve strapping a reactor to a large iceberg lassoed from the Ort belt and accelerating for one half of the trip, then decelerating for the other half.<p>Space travel will require space mining (uranium, water, gold, titanium, lithium, etc)<p>Think of all the things involved: mining equipment, (robots) depots, transport, refueling stations, distribution. SpaceX has already shown vast industries are going to be largely robotic. But people will go to the same places as the mining, because something will always go wrong with something, and those will be the well-developed trade routes.<p>Those people will have all the same issues they have here. Governance, gambling, hepatitis, surgery. But there will be new issues as well. There will likely be founder effect: segments of humanity will venture off to planets many light years away. It will take decades to get there. How do you maintain the concept of "humanity" if they land on a planet with slightly more gravity, slightly colder, slightly less oxygen, so everyone becomes what we would consider a furry dwarf with an IQ of 170?<p>Synthetic genomics will be big in all sorts of ways, some related to the founder effects of space travel.<p>We will not travel faster than the speed of light and hibernation is a fiction. Our bodies just aren't made for that. I think this is a thing people haven't started really planning for very well. Interstellar travel is going to involve very large vessels.<p>but once we do Mars and the asteroid belt, there's not much left in this system.