As long as stand out means - that they don't follow the grid system (not saying they have to); but are also poor in usability and ... last but not least - so far outside the box they look like they tried too hard...<p>No thanks, I'll take a working commerce site of a trendy one every day.
So in other words, actually be a designer rather than a programmer parading around as one? Masquerading under the "cloak of usability" is no substitute for actually being creative. It is, however, a framework for bureaucratic meddling and covering your ass for a lack of talent.