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More evidence emerges for 'transmissible Alzheimer's' theory

171 点作者 randomname2超过 9 年前

5 条评论

JoshTriplett超过 9 年前
Somewhat misleading headline; critical quote from the article: &quot;Neither study implies that Alzheimer’s disease could ever be transmitted through normal contact with caretakers or family members, the scientists emphasize.&quot;<p>This study purely covered transmission via a specific kind of transplant. Still important for understanding the disease, though.
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alexholehouse超过 9 年前
Both this result and the preceding paper are also entirely consistent with the hypotheses that:<p>1) People who are susceptible to vCJD are more susceptible to AD<p>2) The (cellular) stress caused by vCJD increases susceptibility for AD<p>3) People who have had brain surgery (a traumatic and stressful experience in terms of brain swelling) are more susceptible to AD<p>All three of which would be entirely inline with the fields&#x27; current way of thinking about AD, proteostasis, CBI etc. Which is not to say I actually don&#x27;t think that there is a transmissible element, but I think we should avoid jumping to conclusions...
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Someone1234超过 9 年前
Does this improve the likelihood that it is treatable?<p>Some previous theories had been that Alzheimer&#x27;s was essentially genetic. But never fully genetic, instead of guaranteeing your chance of getting it, it just increases the likelihood.<p>So my question is: Could this hint at Alzheimer&#x27;s being the result of some yet undetected infection in the brain that some people are more prone to due to genetics, and that is transmitted due to brain tissue sharing?<p>PS - What I am asking about isn&#x27;t that far from the latest research, see: <a href="http:&#x2F;&#x2F;www.medscape.com&#x2F;viewarticle&#x2F;574944_4" rel="nofollow">http:&#x2F;&#x2F;www.medscape.com&#x2F;viewarticle&#x2F;574944_4</a>
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andrewclunn超过 9 年前
Anecdotally, I am aware that many in my family who developed alzheimer&#x27;s (it runs on both side of my family) has surgery a few years before the disease started to present itself. Though the likelihood of there being much of a connection seems far fetched, even with this latest evidence, I have suddenly become much more concerned about going under the knife until this is all worked out. The grafts I get, but that proteins lingering on equipment, which isn&#x27;t ordinarily removed through standard sterilization, could be a means of transmission... scary.
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clord超过 9 年前
Could it be that Alzheimer&#x27;s plaque is the ultimate expression of an attempt by the body to deal with CJD?
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